血脂和甲状腺激素与甲状腺乳头状癌颈部淋巴结转移的相关性分析  

Correlation analysis of blood lipids,thyroid hormones and cervical lymph node metastasis of thyroid papillary carcinoma

作　　者：何成跃 郑远航 肖凌晖[3] He Cheng-yue;Zheng Yuan-hang;Xiao Ling-hui(Department of General Surgery,Huizhou Huakang Hospital,Huizhou 516000,China;Department of Otolaryngology,Huizhou Huakang Hospital,Huizhou 516000,China;Department of Gastrointestinal and Thyroid Surgery,Huizhou First People’s Hospital,Huizhou 516000,China)

机构地区：[1]惠州华康医院普外科,广东惠州516000 [2]惠州华康医院耳鼻喉科,广东惠州516000 [3]惠州市第一人民医院胃肠甲状腺外科,广东惠州516000

出　　处：《医学食疗与健康》2022年第8期1-4,共4页Medical Diet and Health

基　　金：惠州市科技计划项目(2021WC0106079)。

摘　　要：目的:观察分析血脂及甲状腺激素与甲状腺乳头状癌(PTC)颈部淋巴结转移的相关性。方法:选取惠州华康医院普外科2019年3月至2021年3月收治的300例经术后病理确诊的PTC患者,根据是否存在颈部淋巴结转移分为转移组(96例)和非转移组(204例)。收集两组患者临床资料,检测血脂、甲状腺激素及其功能指标,采用多因素Logistic回归分析血脂、甲状腺激素与PTC颈部淋巴结转移的相关性。结果:两组患者性别、年龄、饮酒、吸烟、家族史、肿瘤数量、收缩压、舒张压及高密度脂蛋白胆固醇指标对比,差异无统计学意义(P>0.05);转移组肿瘤直径>1.cm、促甲状腺激素(TSH)>5.00.U/L、甲状腺球蛋白抗体>130.70.μg/L、抗甲状腺过氧化物酶抗体>100.IU/.mL,占比分别为61.46%、59.14%、52.08%和44.79%,明显高于非转移组的44.12%、37.75%、40.20%和30.88%(P<0.05),转移组三酰甘油(TG)为(3.26±1.04)mmol/L、总胆固醇(TC)为(6.82±1.15)mmol/L、低密度脂蛋白胆固醇(LDL-C)水平为(4.52±1.26)mmol/L,明显高于非转移组的(2.04±0.61).mmol/.L、(6.04±1.03)mmol/L、(3.67±1.04).mmol/L(P<0.05)。多因素Logistic回归分析结果显示,TG、TC、LDL-C水平升高及TSH>5.00.U/L是PTC颈部淋巴结转移的危险因素。结论:血脂异常和TSH与PTC颈部淋巴结转移相关。Objective:To observe and analyze the correlation between blood lipids and thyroid hormones and cervical lymph node metastasis of thyroid papillary carcinoma(PTC).Method:A total of 300 patients with PTC diagnosed by postoperative pathology who were admitted to the Department of General Surgery of Huakang Hospital in Huizhou from March 2019 to March 2021 were selected and divided into a metastasis group(96 cases)and a non-metastasis group(204 cases)according to whether there was cervical lymph node metastasis.The clinical data of the two groups of patients were collected,blood lipids,thyroid hormones and their functional indicators were detected,and the correlation between blood lipids,thyroid hormones and PTC cervical lymph node metastasis was analyzed by multivariate Logistic regression.Result:There was no statistically significant difference in gender,age,alcohol consumption,smoking,family history,tumor number,diastolic blood pressure,systolic blood pressure and high-density lipoprotein cholesterol indexes between the two groups of patients(P>0.05).The proportion of metastasis group tumor diameter>1 cm,thyroid-stimulating hormone(TSH)>5.00 U/L,thyroglobulin antibody>130.70μg/L,anti-thyroid peroxidase antibody>100 IU/mL,They were 61.46%,59.14%,52.08%and 44.79%,which were significantly higher than those of the non-metastatic group of 44.12%,37.75%,40.20%and 30.88%(P<0.05),the triacylglycerol(TG)of the metast-atic group was(3.26±1.04)mmol/L,the total cholesterol(TC)was(6.82±1.15)mmol/L,and the low-density lipoprotein cholesterol(LDL-C)level was(4.52±1.26)mmol/L,significantly higher than the non-metastatic group(2.04±0.61)mmol/L,(6.04±1.03)mmol/L,(3.67±1.04)mmol/L(P<0.05).Multivariate logistic regression analysis showed that elevated levels of TG,TC,LDL-C and TSH>5.00 U/L were risk factors for cervical lymph node metastasis in PTC.Conclusion:Dyslipidemia and TSH are associated with cervical lymph node metastasis of PTC.

关 键 词：血脂 甲状腺激素 甲状腺乳头状癌 颈淋巴结转移 

分 类 号：R736.1.[医药卫生—肿瘤]