双相障碍患者血清5-HT、TPH水平与临床特征的相关性  

Correlations among serum 5-HT and TPH levels and clinical features in patients with bipolar disorder

作　　者：于婷 YU Ting(The Seventh Medical Department of Yantai Psychological Rehabilitation Hospital,Yantai 265200 Shandong,China)

机构地区：[1]烟台市心理康复医院医疗七科,山东烟台265200

出　　处：《中国民康医学》2022年第9期60-62,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨双相障碍患者血清5-羟色胺(5-HT)、色氨酸羟化酶(TPH)水平与临床特征的相关性。方法:选取2018年9月至2020年2月该院收治的62例双相障碍患者设为观察组,另选取同期50名该院健康检查者为对照组。观察组根据有、无童年创伤分为A组(n=30)和B组(n=32)。比较观察组和对照组血清5-HT、TPH水平;比较A组和B组抑郁、躁狂发作次数和发作时间以及社会功能评定量(SSPI)评分;采用Pearson相关性分析双相障碍患者血清5-HT、TPH水平与抑郁、躁狂发作次数、发作时间及SSPI评分的相关性。结果:观察组血清5-HT、TPH水平均低于对照组,差异有统计学意义(P<0.05);A组抑郁、躁狂发作次数均多于B组,抑郁、躁狂发作时间长于B组,差异有统计学意义(P<0.05);A组日常生活能力、社会性活动技能和SSPI总分显著低于B组,差异均有统计学意义(P<0.05);血清5-HT、TPH水平与双相障碍患者抑郁发作次数、躁狂发作次数和SSPI评分呈负相关(P<0.05);血清5-HT水平与躁狂发作时间呈负相关(P<0.05)。结论:双相障碍患者血清5-HT和TPH水平低于健康体检者,血清5-HT、TPH水平与双相障碍患者抑郁发作次数、躁狂发作次数和SSPI评分呈负相关。Objective:To explore correlations among serum 5-hydroxytryptamine(5-HT)and tryptophan hydroxylase(TPH)expression levels and clinical features in patients with bipolar disorder.Methods:62 patients with bipolar disorder who were treated in our hospital from September 2018 to February 2020 were selected as the research objects and were set as observation group.50 healthy subjects were selected as control group during the same period.The observation group were further divided into group A(n=30)and group B(n=32)according to whether there was childhood trauma.The serum levels of 5-HT and TPH in the observation group and the control group were compared.The number of depressive and manic episodes,the duration of episodes,and the scale of social function in psychosis inpatient(SSPI)score were compared between groups A and B.Pearson’s statistical method was used to analyze the correlations of the serum 5-HT and TPH levels with the number of depressive and manic episodes,the duration of episodes and the SSPI score in the patients with bipolar disorder.Results:The serum levels of 5-HT and TPH in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The number of depressive and manic episodes in group A was more than that in group B;the duration of episodes was longer than that in group B;and the differences were statistically significant(P<0.05).The daily living ability score,the social activity skills score and the SSPI total score of group A were significantly lower than those of group B,and the differences were statistically significant(P<0.05).The serum levels of 5-HT and TPH were negatively correlated with the number of depressive and manic episodes,the duration of episodes and the SSPI score in the patients with bipolar disorder(P<0.05),and the serum level of 5-HT was negatively correlated with the duration of episodes(P<0.05).Conclusions:The serum levels of 5-HT and TPH in the patients with bipolar disorder are lower than those in the healthy subjec

关 键 词：双相障碍 临床特征 相关性 血清5-羟色胺 血清色氨酸羟化酶 

分 类 号：R749.4[医药卫生—神经病学与精神病学]