人脐带间充质干细胞分泌因子脂质体治疗黑素细胞痣激光治疗后皮肤损伤疗效观察  

Effect of Human Umbilical Cord Mesenchymal Stem Cell Secretory Factor Liposome on Skin Damage after Laser Treatment of Melanocytic Nevus

作　　者：袁佩雯 王培森 侯秀英[2] 李勤雨 李丽[2] 张宝林[2] 聂君毅 彭艳 YUAN Peiwen;WANG Peisen;HOU Xiuying;LI Qinyu;LI Li;ZHANG Baolin;NIE Junyi;PENG Yan(The First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,Shanxi,China;The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院,山西太原030001

出　　处：《中国美容医学》2022年第5期10-13,共4页Chinese Journal of Aesthetic Medicine

基　　金：山西省重点研发计划(编号:201603D321080)。

摘　　要：目的:探讨人脐带间充质干细胞分泌因子脂质体用于黑素细胞痣激光治疗后皮肤损伤的疗效。方法:将56例激光治疗后的黑素细胞痣患者随机分为对照组和治疗组各28例,对照组术后用空白脂质体涂抹治疗,治疗组术后用人脐带间充质干细胞分泌因子脂质体涂抹治疗,比较两组患者的损伤反应、伤口愈合时间、皮肤镜下愈合情况及总有效率。结果:术后不同时间点两组损伤反应评分呈递减趋势,术后2 d及术后4 d治疗组损伤反应弱于对照组(P<0.05),治疗组伤口愈合时间明显短于对照组(P<0.05),皮肤镜下愈合情况优于对照组,总有效率(100.00%)显著高于对照组(78.57%,P<0.05)。结论:人脐带间充质干细胞分泌因子脂质体用于黑素细胞痣激光治疗后皮肤损伤有较好疗效,值得临床推广应用。Objective To observe the therapeutic effect of human umbilical cord mesenchymal stem cell secretory factor liposome on skin injury of melanocyte nevus after laser treatment.Methods 56 cases of melanocyte nevus after laser treatment of the patients were randomly divided into control group and treatment group.The control group was treated with blank liposome and the treatment group was treated with human umbilical cord mesenchymal stem cell secretory factor liposome.The injury response,wound healing time,cutaneous healing and total eff ective rate were compared between the two groups.Results The injury response scores of the two groups at diff erent postoperative time points showed a decreasing trend,and the injury response of the treatment group at all other time points except 0 d after surgery was weaker than that of the control group(P<0.05),and the wound healing time was signifi cantly shorter than that of the control group(P<0.05),the healing condition under dermoscopy was better than that of the control group,and the total eff ective rate(100.00%)was higher than that of the control group(78.57%,P<0.05).Conclusion Human umbilical cord mesenchymal stem cell secretory factor liposome has a signifi cant eff ect on skin injury after laser treatment of melanocyte nevus.It is worthy of clinical application.

关 键 词：人脐带 间充质干细胞 脂质体 创面修复 激光 黑素细胞痣 

分 类 号：R739.5[医药卫生—肿瘤]