神经内镜扩大经鼻蝶切除术治疗颅咽管瘤的临床效果及安全性探讨  

Clinical Efficacy and Safety of Neuroendoscope Extended Transnasal Sphenectomy for Craniopharyngioma

作　　者：杨波[1] 魏晨斌[1] YANG Bo;WEI Chenbin(Fujian Provincial Hospital,Fuzhou 350001,China;不详)

机构地区：[1]福建省立医院,福建福州350001

出　　处：《中外医学研究》2022年第12期129-131,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨神经内镜扩大经鼻蝶切除术治疗颅咽管瘤的临床效果及安全性。方法:按照简单随机化法将福建省立医院神经外科2019年10月-2021年4月160例颅咽管瘤患者分组,对照组(80例)给予传统开颅切除术治疗,观察组(80例)给予神经内镜扩大经鼻蝶切除术治疗。对比两组手术时间、术中出血量、住院时间、肿瘤全切率及并发症情况。结果:观察组与对照组相比,住院时间明显较短(P<0.05);两组术中出血量、手术时间比较,差异无统计学意义(P>0.05);观察组与对照组的肿瘤全切率分别为66.25%和47.50%,临床缓解率分别为88.75%和56.25%,观察组均明显较高(P<0.05);观察组与对照组的并发症总发生率分别为13.75%和28.75%,观察组低于对照组(P<0.05)。结论:神经内镜扩大经鼻蝶切除术可有效提高颅咽管瘤患者的临床疗效,并且安全性良好。Objective:To investigate the clinical efficacy and safety of neuroendoscopic expanded transnasal sphenoid resection in the treatment of craniopharyngioma.Method:According to the simple randomization method,160 patients with craniopharyngioma from October 2019 to April 2021 in the department of neurosurgery of Fujian Provincial Hospital were divided into two groups.The control group(80 cases)was treated with traditional craniotomy,and the observation group(80 cases)was treated with neuroendoscopic expanded transnasal sphenoid resection.The operation time,intraoperative blood loss,hospitalization time,total tumor resection rate and complications were compared between the two groups.Result:Compared with the control group,the observation group had a significantly shorter hospitalization time(P<0.05).There were no statistical differences in the amount of intraoperative blood loss and operation time between the two groups(P>0.05).The total tumor resection rates of observation group and control group were 66.25%and 47.50%respectively,and the clinical remission rates were 88.75%and 56.25%respectively,which were significantly higher in the observation group(P<0.05).The total incidence of complications of the observation group and the control group were 13.75%and 28.75%,respectively,the observation group was lower than the control group(P<0.05).Conclusion:Neuroendoscopic expanded transnasal sphenoid resection can effectively improve the clinical efficacy of patients with craniopharyngioma,and it is safe.

关 键 词：颅咽管瘤 神经内镜扩大经鼻蝶切除术 临床疗效 安全性 

分 类 号：R739.41[医药卫生—肿瘤]