局部晚期宫颈癌患者根治性子宫切除联合术前卡铂与紫杉醇密集化疗的安全性及有效性  

Efficacy and safety of carboplatin plus dose-dense weekly paclitaxel before radical hysterectomy in patients with locally advanced cervical cancer

作　　者：范阿童 FAN A-tong(Department of Obstetrics and Gynecology,Panjin Central Hospital,Panjin 124000,China)

机构地区：[1]盘锦市中心医院妇产院区产科,辽宁盘锦124000

出　　处：《实用药物与临床》2022年第5期404-407,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨卡铂与紫杉醇密集化疗联合根治性子宫切除术治疗局部晚期宫颈癌患者的有效性及安全性。方法选取2018年1月至2019年1月我院收治的行根治性子宫切除术的局部晚期宫颈癌患者41例,随机分为对照组(21例)和观察组(20例)。对照组行常规卡铂+紫杉醇化疗;观察组行卡铂+剂量密集紫杉醇化疗,化疗结束后2~3周,两组患者均接受根治性子宫切除术及盆腔淋巴结清扫术。比较两组患者的近期疗效、不良反应发生情况、术后淋巴结转移和复发情况及无进展生存率和总生存率。结果观察组化疗后客观有效率(ORR)高于对照组(80.00%vs.47.62%,P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。观察组术后淋巴结转移2例(10%),显著少于对照组[8例(38.10%)]。观察组术后复发率略低于对照组(15%vs.42.86%),但差异无统计学意义(P>0.05)。观察组和对照组的2年无进展生存(PFS)率分别为88.89%和65.62%,差异无统计学意义(P>0.05)。观察组和对照组的2年总生存(OS)率分别为94.12%和77.20%,差异无统计学意义(P>0.05)。结论剂量密集TC治疗与常规化疗相比,在局部晚期宫颈癌患者中显示出更好的疗效,不良反应相当,可在不降低生存率的前提下大大降低化疗/同步放化疗的使用。Objective To explore the efficacy and safety of carboplatin plus dose-dense weekly paclitaxel before radical hysterectomy in patients with locally advanced cervical cancer.Methods Totally 41 patients with locally advanced cervical cancer treated in our hospital from January 2018 to January 2019 were randomly assigned into control group(n=21)and observation group(n=20).Patients in control group were treated with traditional carboplatin-paclitaxel,and patients in observation group received carboplatin plus dose-dense weekly paclitaxel.At 2~3 weeks after stopping chemotherapy,the two groups of patients received radical hysterectomy and pelvic lymph mode dissection.The objective response rate(ORR),adverse events,lymph-node metastasis,recurrence rate and survival of the two groups were recorded and compared.Results The ORR of observation group was higher than that of control group(80.00%vs.47.62%,P<0.05),and there was no significant difference in the incidence rate of adverse events(P>0.05).The proportion of lymph-node metastasis in observation group(10%,2/20)was significantly lower than that in control group(38.10%,8/21).The recurrence rate in observation group was slightly lower than that in control group,but there was no significant difference(P>0.05).The 2-year PFS and OS in observation group were slightly higher than those in control group(65.62%vs.77.20%),but there was no significant difference(P>0.05).Conclusion Compared with conventional chemotherapy,carboplatin plus dose-dense weekly paclitaxel regimen results in higher efficacy with similar adverse events in patients with 10 locally advanced cervical cancer,and it can greatly reduce the application of radiation therapy with equivalent survival.

关 键 词：局部晚期宫颈癌 剂量密集化疗 卡铂 紫杉醇 

分 类 号：R737.33[医药卫生—肿瘤]