CD47分子相关信号通路及CD47在病原感染中的研究进展  

Research Progress of CD47-Related Signaling Pathway and the Role of CD47 in Pathogenic Infection

作　　者：陈婧 黄泽宇[2] 周学东[1] 程磊[1] CHEN Jing;HUANG Ze-yu;ZHOU Xue-dong;CHENG Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Department of Orthopaedic Surgery,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院牙体牙髓病科,成都610041 [2]四川大学华西医院骨科,成都610041

出　　处：《四川大学学报（医学版）》2022年第3期523-527,共5页Journal of Sichuan University(Medical Sciences)

基　　金：国家重点研发计划课题(No.2017YFC0840107)资助。

摘　　要：CD47是一种广泛表达于细胞表面的跨膜糖蛋白,是细胞逃逸固有免疫监视的重要检查点之一。其参与调控的信号通路以及表达水平的改变在免疫调节、病原感染以及抗肿瘤免疫中发挥的重要作用也逐步被人们所认识。本文从CD47的结构与生物学特性,CD47与配体整合素、凝血栓蛋白1以及信号调节蛋白结合所作用的信号转导过程,病原体感染促进宿主CD47表达及CD47在不同感染免疫应答的作用这三个方面进行了文献综述,并对未来CD47靶向免疫治疗在感染相关肿瘤中的应用前景进行了展望,为今后的研究提供一定参考。CD47,a transmembrane glycoprotein widely expressed on the cell surface,is one of the important checkpoints through which cells escape innate immune surveillance.The important role of CD47-related signaling pathway and changes in expression level in immune regulation,pathogen infection and anti-tumor immunity has gradually come to be recognized.We reviewed herein the structure and biological characteristics of CD47,the interaction and the downstream signaling of CD47 with integrin,thrombospondin 1,and signal regulatory protein,and the upregulated expression of CD47 induced by the infection of different pathogens and the role of CD47 in different types of immune response to infection.Discussions were made regarding the prospective application of CD47 targeted immunotherapy in pathogenic infection-related cancers,intending to provide guidance for future research.

关 键 词：CD47 感染 免疫治疗 肿瘤 

分 类 号：R363[医药卫生—病理学]