HPV检查对预防宫颈癌前病变及宫颈癌的临床价值研究  

Study on the Clinical Value of HPV Examination in Preventing Cervical Precancerous Lesions and Cervical Cancer

作　　者：李会 LI Hui(Department of Obstetrics and Gynecology,Maternal and Child Health and Family Planning Service Center of Jinxiang County,Jining,Shandong Province,272200 China)

机构地区：[1]金乡县妇幼保健计划生育服务中心妇产科,山东济宁272200

出　　处：《中外医疗》2022年第6期34-37,共4页China & Foreign Medical Treatment

摘　　要：目的探讨HPV检查对宫颈癌前病变及宫颈癌的临床价值。方法方便选取2019年1月—2021年8月在该院进行宫颈筛查的4464例女性,均行HPV-DNA检测,分析阳性检出率,HPV亚型的分布特点;对于检测阳性的患者,进行阴道镜和病理检测,对宫颈癌前病变及宫颈癌进行确诊,分析HPV亚型的特点,高危型HPV感染率。结果HPV-DNA筛查后,4464例女性中检出523例阳性患者,其中137例HPV-52,77例HPV-16,57例HPV-6,38例HPV-58,26例HPV-18,22例HPV-44,21例HPV-56;523例阳性患者中,经阴道镜和病理确诊后有低级别115例,高级别300例,宫颈癌108例。宫颈癌前病变及宫颈癌高危型HPV感染率比较,差异有统计学意义(P<0.05),低级别主要以HPV-16、35、39高危型为主,高级别主要以HPV-16、52、58高危型为主,宫颈癌主要以HPV-16、18、33、52、58高危型为主。结论宫颈癌前病变及宫颈癌均与高危型HPV有关,宫颈癌前病变以HPV-16、52、58高危型为主,宫颈癌主要以HPV-16、18、33、52、58高危型为主。因此高危型的筛查对于预防癌前病变及宫颈癌具有重要价值。Objective To explore the clinical value of HPV examination for cervical precancerous lesions and cervical cancer.Methods Random selected 4464 women who underwent cervical screening in this hospital from January 2019 to August 2021.All of them underwent HPV-DNA testing to analyze the positive detection rate and the distribution characteristics of HPV subtypes.For positive patients,underwent colposcopy and pathological testing to diagnose cervical precancerous lesions and cervical cancer.Analyzed the characteristics of HPV subtypes and the infection rate of high-risk HPV.Results After HPV-DNA screening,523 positive patients were detected out of 4464 women.Among them,137 cases of HPV-52,77 cases of HPV-16,57 cases of HPV-6,38 cases of HPV-58,26 cases of HPV-18,22 cases of HPV-44,21 cases of HPV-56.Among the 523 positive patients,115 were low-grade,300 were high-grade,and 108 were cervical cancer after colposcopy and pathological diagnosis.The comparison between cervical precancerous lesions and cervical cancer for high-risk HPV infection rates,the difference was statistically significant(P<0.05).Low-level was mainly HPV-16,HPV-35,HPV-39 high-risk types,and high-level HPV-16,52,58 high-risk types was the main ones,cervical cancer was mainly HPV-16,HPV-18,HPV-33,HPV-52,HPV-58 high-risk types.Conclusion Cervical precancerous lesions and cervical cancer are all related to high-risk HPV.Cervical precancerous lesions are mainly HPV-16,HPV-52,HPV-58 high-risk types,and cervical cancers are mainly HPV-16,HPV-18,HPV-33,HPV-52,HPV-58 high-risk types.Therefore,high-risk screening is of great value for preventing precancerous lesions and cervical cancer.

关 键 词：高危型HPV感染 宫颈癌前病变 宫颈癌 阴道镜 HPV-DNA 

分 类 号：R73[医药卫生—肿瘤]