血清sCD14、CRP、PCT在急性胰腺炎中的表达及与APACHEⅡ、BISAP的相关性  

Expression of Serum sCD14,CRP and PCT in Acute Pancreatitis and their Correlation with APACHE Ⅱ and BISAP

作　　者：张磊 王梅英[1] 王瑞刚 冯蕊 董俊婵[1] 宋智勇 侯云生[1] ZHANG Lei;WANG Mei-ying;WANG Rui-gang;FENG Rui;DONG Jun-chan;SONG Zhi-yong;HOU Yun-sheng(Department of 1 Emergency Medicine the 98th Hospital(formerly of Bethune International Peace Hospital),Shijiazhuang,Hebei,050051,China;Department of Emergency Medicine,Affiliated Hospital of North China University of Technology,Tangshan,Hebei,063000,China)

机构地区：[1]联勤保障部队第九八〇医院(原白求恩国际和平医院)急诊医学科,河北石家庄050051 [2]华北理工大学附属医院急诊医学科,河北唐山063000

出　　处：《现代生物医学进展》2022年第8期1510-1513,1595,共5页Progress in Modern Biomedicine

基　　金：河北省卫健委科研计划项目(20200245)。

摘　　要：目的:探讨血清可溶性白细胞分化抗原14(s CD14)、C反应蛋白(CRP)、降钙素原(PCT)在急性胰腺炎中的表达及与急性生理功能和慢性健康状况评分系统Ⅱ(APACHEII)、急性胰腺炎严重程度床边指数(BISAP)的相关性。方法:选择2019年1月~2021年1月于我院进行治疗的急性胰腺炎患者150例患者进行研究,设为病例组,并选择我院同期体检健康者50例作为对照组,分析患者血清s CD14、CRP、PCT水平变化情况及与APACHEⅡ、BISAP之间的相关性。结果:病例组患者血清s CD14、CRP、PCT及APACHEⅡ、BISAP水平均显著高于对照组,差异显著(P<0.05);轻度患者血清s CD14、CRP、PCT及APACHEⅡ、BISAP水平均显著低于中度、重度患者,中度患者血清s CD14、CRP、PCT及APACHEⅡ、BISAP水平均显著低于重度患者,差异显著(P<0.05);相关性分析结果显示,血清s CD14、CRP、PCT与APACHEⅡ、BISAP之间均呈正相关(r=0.449,0.649,0.584,0.488,0.674,0.663,P<0.05)。结论:急性胰腺炎患者血清s CD14、CRP、PCT均呈高表达,且与APACHEⅡ、BISAP密切相关。Objective: To studyExpression of serum Soluble Differentiation antigen 14(s CD14), C-reactive protein(CRP), procalcitonin(PCT) in acute pancreatitis and their correlation with Acute physiological function and chronic health status scoring system Ⅱ(APACHEII), bedside acute pancreatitis severity index(BISAP). Methods: 150 patients with acute pancreatitis who were treated in our hospital from January 2019 to January 2021 were selected as the case group, and 50 healthy patients who were examined in our hospital during the same period were selected as the control group. The changes of serum s CD14, CRP and PCT levels and their correlation with APACHE Ⅱ and BISAP were analyzed. Results: The serum levels of s CD14, CRP, PCT, APACHE Ⅱ and BISAP in case group were significantly higher than those in control group, with significant differences(P<0.05);The serum levels of s CD14, CRP, PCT, APACHEⅡ and BISAP in mild patients were significantly lower than those in moderate and severe patients, and the serum levels of s CD14, CRP,PCT, APACHE Ⅱ and BISAP in moderate patients were significantly lower than those in severe patients, with significant differences(P<0.05). Correlation analysis results showed that serum s CD14, CRP and PCT and APACHE Ⅱ, there was a positive correlation between BISAP(r=0.449, 0.649, 0.584, 0.488, 0.674, 0.663, P<0.05). Conclusion: Serum s CD14, CRP and PCT were highly expressed in patients with acute pancreatitis, and were closely related to APACHE Ⅱ and BISAP.

关 键 词：可溶性白细胞分化抗原14 C反应蛋白 降钙素原 急性胰腺炎 急性生理功能和慢性健康状况评分系统Ⅱ 急性胰腺炎严重程度床边指数 相关性 

分 类 号：R576[医药卫生—消化系统]