外周血CTC、VEGF的水平与晚期非小细胞肺癌临床特征及化疗疗效关系的研究  

Study on the Relationship between CTC and VEGF Levels in Peripheral Blood and Clinical Features and Chemotherapy Efficacy of Advanced Non-small Cell Lung Cancer

作　　者：宋佳烨 曹永峰[1] 季进锋[1] 黄晋博 沈芹 季璇 SONG Jia-ye;CAO Yong-feng;JI Jin-feng;HUANG Jin-bo;SHEN Qin;JI Xuan(Deparment of Medical Oncology,Tumor Hospital Affiliated to Nantong University,Nantong,Jiangsu,226361,China;Deparment of Respiratory medicine,Affiliated Hospital of Nantong University,Nantong,Jiangsu,226006,China;Deparment of Infectious disease,Affiliated Hospital of Nantong University,Nantong,Jiangsu,226006,China)

机构地区：[1]南通大学附属肿瘤医院肿瘤内科,江苏南通226361 [2]南通大学附属医院呼吸内科,江苏南通226006 [3]南通大学附属医院感染科,江苏南通226006

出　　处：《现代生物医学进展》2022年第8期1547-1551,1566,共6页Progress in Modern Biomedicine

基　　金：江苏省中医药科技发展计划项目(YB2020067)。

摘　　要：目的:探讨外周血循环肿瘤细胞(CTC)、血管内皮生长因子(VEGF)的水平与晚期非小细胞肺癌临床特征及化疗疗效的关系。方法:选取我院2017年1月到2020年1月收治的80例晚期非小细胞肺癌患者作为研究对象,所有患者均采取一线方案化疗,分析外周血CTC、VEGF的水平与患者的年龄、性别等的关系,并对晚期非小细胞肺癌化疗疗效进行单因素与多因素COX分析。结果:CTC、VEGF与不同性别、年龄患者和TNM分期无明显关系(P>0.05),与淋巴结转移、肿瘤分化程度、肿瘤大小有关(P<0.05);80例患者中,客观缓解率(ORR)为51.25%(41/80),疾病控制率(DCR)为71.25%(57/80);淋巴结转移、肿瘤分化程度、CTC和血清VEGF水平为晚期非小细胞肺癌患者ORR、DCR的影响因素(P<0.05);COX分析分析表明:肿瘤中、低分化、CTC阴性、VEGF降低为晚期非小细胞肺癌化疗ORR和DCR提升的独立影响因素(P<0.05)。结论:外周血CTC、VEGF检测对于晚期非小细胞肺癌化疗近远期疗效评估具有重要价值,属于预后独立影响因素。因此,CTC、VEGF可作为晚期非小细胞肺癌的预后及疗效判断的指标。Objective: To investigate the relationship between the levels of CTC and VEGF in peripheral blood and the clinical characteristics and chemotherapy efficacy of advanced non-small NSCLC. Methods: A total of 80 patients with advanced non-small cell lung cancer admitted to our hospital from January 2017 to January 2020 were selected as the research objects, and they were treated with first-line chemotherapy. The relationship between the levels of CTC and VEGF in peripheral blood and the age and gender of patients was analyzed. Univariate and multivariate COX analysis was performed on the efficacy of chemotherapy for advanced NSCLC. Results:CTC and VEGF had no significant relationship with patients of different genders and ages and TNM stage(P>0.05), but were related to lymph node metastasis, tumor differentiation degree and tumor size(P<0.05);The ORR was 51.25 %(41/80) and DCR was 71.25 %(57/80) in 80 patients;Lymph node metastasis, tumor differentiation, CTC and serum VEGF levels were the influencing factors of ORR and DCR in patients with advanced NSCLC(P<0.05);COX analysis showed that: The moderate and poorly differentiated tumors, negative CTC and decreased VEGF were independent factors affecting the increase of Orr and DCR in advanced non-small cell lung cancer(P<0.05). Conclusion: The detection of CTC and VEGF in peripheral blood is of great value for the evaluation of short-term and long-term efficacy of chemotherapy in advanced NON-small cell lung cancer, which are independent prognostic factors. Therefore, CTC and VEGF can be used as prognostic and therapeutic indicators of advanced NSCLC.

关 键 词：非小细胞肺癌 循环肿瘤细胞 血管内皮生长因子 

分 类 号：R734.2[医药卫生—肿瘤]