唾液腺及唾液腺肿瘤类器官的研究进展  

Development and future promise of salivary gland organoids and salivary gland tumor organoids

作　　者：王博 穆亚冰 臧光祥 Wang Bo;Mu Yabing;Zang Guangxiang(Department of Pathology,School and Hospital of Stomatology,China Medical University,Shenyang 110002,China)

机构地区：[1]中国医科大学口腔医学院·附属口腔医院病理科,辽宁省口腔疾病重点实验室,沈阳110002

出　　处：《中华口腔医学杂志》2022年第5期535-539,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82072998,82173322)。

摘　　要：唾液腺是口腔颌面部的重要器官,环境和遗传因素导致唾液腺肿瘤和非肿瘤性疾病的发生,但其具体发生机制,并不十分清楚,其中一个重要原因是研究对象和研究模型较为缺乏。类器官作为一种新的技术体系和研究方法,已经被广泛应用于多种疾病的研究中,它是连接二维细胞培养和活体动物模型的重要桥梁,也是连接临床医学和基础研究的非常有潜力的转化模型。本文就正常唾液腺及唾液腺肿瘤类器官的研究进展,及其在组织工程、病因学研究、肿瘤治疗中的应用,以及未来面临的挑战等方面进行综述。Salivary glands are important organs in the oral and maxillofacial region.Environment and genetic factors may cause salivary gland tumors or non-neoplastic diseases,but the mechanisms of those diseases are still unclear.One of the important reasons is the short of researching media and model.As a new technique and research model,organoids have been widely used in the research of various diseases.Organoid culture plays a bridging role between two-dimensional cell culture and living animal models,and it is also the most promising translational research model that could connect the clinical research to basic research.This review will discuss the recent development of organoid techniques in the culture of normal salivary glands and salivary gland tumors,also their applications and challenges in tissue engineering,etiological research,and tumor therapy.

关 键 词：唾液腺 唾液腺肿瘤 类器官 

分 类 号：R739.87[医药卫生—肿瘤]