对比观察不可逆电穿孔与射频消融治疗肝癌  

Comparative observation of irreversible electroporation and radiofrequency ablation in treatment of liver cancer

作　　者：李学达[1] 杨莉莉[1] 张浩[1] 刘国平[1] 张伟[1] 李伟[1] 刘士锋[1] 王从晓 王松[1] 胡效坤[1] LI Xueda;YANG Lili;ZHANG Hao;LIU Guoping;ZHANG Wei;LI Wei;LIU Shifeng;WANG Congxiao;WANG Song;HU Xiaokun(Interventional Medical Center, the Affiliated Hospital of Qingdao University, Qingdao 266000, China)

机构地区：[1]青岛大学附属医院介入医学中心,山东青岛266000

出　　处：《中国介入影像与治疗学》2022年第6期325-328,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的对比观察不可逆电穿孔(IRE)与射频消融治疗肝癌的安全性及疗效。方法前瞻性纳入48例肝癌患者,随机将其分为试验组及对照组,每组24例。对试验组于全身麻醉下行CT引导下IRE消融;对照组于局部麻醉下行CT引导下射频消融;记录术中及术后不良反应,对比评价疗效。结果对2组患者均顺利完成治疗,试验组1例死于对比剂过敏性休克,其余患者均未发生治疗相关3~4级严重不良反应及并发症。组间术后7天肿瘤消融成功率(96.43%vs.96.97%)、术后30天(96.43%vs.93.94%)及90天(89.29%vs.90.91%)局部无复发率差异均无统计学意义(P均>0.05);术后各时间点总缓解率及疾病控制率差异亦无统计学意义(P均>0.05)。结论IRE消融治疗肝癌效果明确、安全性高、不良反应轻,其局部控制肿瘤效果与射频消融治疗相当。Objective To compare the safety and efficacy of irreversible electroporation(IRE)and radiofrequency ablation in treatment of liver cancer.Methods Forty-eight patients with liver cancer were prospectively collected and randomly divided into experimental group and control group(each n=24).CT-guided IRE ablation was performed under general anesthesia in experimental group,while CT-guided radiofrequency ablation under local anesthesia was performed in control group.The occurrence of intraoperative and postoperative adverse reactions,and the curative effect were evaluated and compared between groups.Results The operations were successfully completed in all patients.One case in experimental group died of contrast medium anaphylactic shock.There was no treatment-related grade 3—4 serious adverse reactions nor complications in both groups,no significant differences of the local recurrence free rate 7 days(96.43%vs.96.97%),30 days(96.43%vs.93.94%)and 90 days(89.29%vs.90.91%)after operations between groups(all P>0.05).No significant differences of the overall response rate nor disease control rate at each time point after operation between groups(all P>0.05).Conclusion IRE ablation had clear efficacy,high safety and light adverse reactions for treatment of liver cancer,with local tumor control effect similar to that of radiofrequency ablation.

关 键 词：肝肿瘤 不可逆电穿孔 射频消融 前瞻性研究 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]