SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节  

SPECT combined with serum adiponectin for differential diagnosis of benign and malignant thyroid nodules

作　　者：张立甲 高毅 姜涵 邱新光[2] ZHANG Lijia;GAO Yi;JIANG Han;QIU Xinguang(Department of Nuclear Medicine, Xinxiang Central Hospital, the Fourth Clinical College of Xinxiang Medical University, Xinxiang 453000, China;Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China)

机构地区：[1]新乡市中心医院新乡医学院第四临床学院核医学科,河南新乡453000 [2]郑州大学第一附属医院甲状腺外科,河南郑州450000

出　　处：《中国介入影像与治疗学》2022年第6期352-355,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：河南省高等学校重点科研项目(18A320008)。

摘　　要：目的分析SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节的效能。方法回顾性分析815例单发甲状腺结节患者,术前均接受甲状腺SPECT显像及血清脂联素水平检测;以术后病理结果为金标准,采用受试者工作特征(ROC)曲线评估SPECT、血清脂联素及二者联合鉴别诊断甲状腺良、恶性结节的效能。结果815枚甲状腺结节中,良性结节777枚(良性组),恶性结节38枚(恶性组),其血清脂联素水平分别为(12.65±1.45)ng/ml及(6.28±0.94)ng/ml,组间差异有统计学意义(P<0.001)。SPECT正确诊断恶性结节30枚、良性结节582枚,其鉴别诊断甲状腺良、恶性结节的曲线下面积(AUC)为0.783。以8.95 ng/ml为血清脂联素的截断点,正确诊断恶性甲状腺结节27例、良性544例,其AUC为0.723。SPECT联合血清脂联素正确诊断26例恶性、653例良性甲状腺结节,AUC为0.901。结论SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节的效能较高。Objective To explore the efficacy of SPECT combined with serum adiponectin for differential diagnosis of benign and malignant thyroid nodules.Methods Data of 815 patients with solitary thyroid nodules were retrospectively analyzed.All patients underwent thyroid SPECT imaging and serum adiponectin level detection before surgical resection.Taken postoperative pathological results as the gold standards,the receiver operating characteristic(ROC)curve was used to evaluate the efficacy of SPECT,serum adiponectin and both for differential diagnosis of benign and malignant thyroid nodules.Results Among 815 thyroid nodules,777 were benign(benign group)and 38 were malignant ones(malignant group),with serum adiponectin levels of(12.65±1.45)ng/ml and(6.28±0.94)ng/ml,respectively,and the difference was statistically significant between groups(P<0.001).SPECT correctly diagnosed 30 malignant nodules and 582 benign nodules,and its area under the curve(AUC)for differentiating benign and malignant thyroid nodules was 0.783.Taken 8.95 ng/ml as the cut-off point of serum adiponectin,27 cases of malignant thyroid nodules and 544 of benign thyroid nodules were correctly diagnosed,with AUC of 0.723.SPECT combined with serum adiponectin correctly diagnosed malignant thyroid nodules in 26 cases and benign thyroid nodules in 653 cases,and the AUC was 0.901.Conclusion SPECT combined with serum adiponectin had high efficacy for differential diagnosis of benign and malignant thyroid nodules.

关 键 词：甲状腺结节 脂联素 体层摄影术 发射型计算机 单光子 诊断 鉴别 

分 类 号：R736.1[医药卫生—肿瘤] R817.4[医药卫生—临床医学]