Nrf2信号通路在脑缺血/再灌注损伤神经保护机制中的研究进展  

Research progress of nuclear factor E 2-related factor 2 signaling pathway in neuroprotective mechanism of cerebral ischemia/reperfusion injury

作　　者：卢志刚 卢青 李钊硕 Lu Zhigang;Lu Qing;Li Zhaoshuo(Department of Neurology,the First People's Hospital of Jingmen Affiliated to Hubei Minzu University,Jingmen 448000,Hubei,China;Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases,Enshi 445000,Hubei,China;Department of Cerebrovascular,Henan Provincial People's Hospital(Zhengzhou University People's Hospital),Zhengzhou 450003,Henan,China)

机构地区：[1]湖北民族大学附属荆门市第一人民医院神经内科,湖北荆门448000 [2]风湿性疾病发生与干预湖北省重点实验室,湖北恩施445000 [3]河南省人民医院(郑州大学人民医院)脑血管病科,河南郑州450003

出　　处：《中华危重病急救医学》2022年第3期325-328,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(82060813);湖北省科技计划项目(2020CFB722);湖北省卫生健康委创新团队项目(WJ2021M075);湖北省荆门市科技计划项目(2020YFZD025);风湿性疾病发生与干预湖北省重点实验室开放基金项目(PT022103)。

摘　　要：脑缺血/再灌注(I/R)损伤指大脑在急性缺血一段时间后再恢复血液供应,却出现脑组织损伤加剧的一种病理现象,其发病机制复杂,包括氧化应激、炎症反应、兴奋性氨基酸毒性等。临床针对缺血性脑卒中(IS)后脑I/R损伤的有效治疗方法有限,核因子E2相关因子2(Nrf2)作为细胞内最关键的抗氧化转录因子,可协调多种细胞保护因子来抑制氧化应激。Nrf2信号通路被认为是对抗氧化应激最重要的细胞防御机制之一,于是靶向Nrf2就成为一种有吸引力的治疗策略,在脑I/R损伤的防治过程中发挥了重要作用。本文围绕Nrf2信号通路的结构、调控、功能以及在脑I/R损伤中的激活和潜在治疗靶点等进行综述,重点阐述Nrf2通路在脑I/R损伤发病机制中的重要作用及未来潜力。Cerebral ischemia/reperfusion(I/R)injury refers to an aggravated brain tissue damage caused by the restoration of blood supply after acute ischemia for a period of time.Its pathogenesis is complex,including oxidative stress,inflammatory response,and excitatory amino acid toxicity.The effective clinical treatments of cerebral I/R injury after ischemic stroke(IS)are limited.Nuclear factor E 2-related factor 2(Nrf2),the most critical antioxidant transcription factor in cells,can coordinate multiple cytoprotective factors to inhibit oxidative stress.Since Nrf2 signaling pathway is considered to be one of the most important cellular defense mechanisms against oxidative stress,targeting Nrf2 intervention has become an attractive therapeutic strategy in the prevention and treatment of cerebral I/R injury.This review focuses on the structure,regulation and function of Nrf2 signaling pathway,as well as its activation and potential therapeutic targets in cerebral I/R injury.The important role and future potential of Nrf2 pathway in the pathogenesis of cerebral I/R injury were discussed.

关 键 词：核因子E2相关因子2信号通路 脑缺血/再灌注损伤 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]