抗gp210抗体在原发性胆汁性胆管炎中的产生机制与检测价值  

Production mechanism and detection value of anti-gp210 antibody in primary biliary cholangitis

作　　者：张继红 李素领[2] ZHANG Jihong;LI Suling(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450000

出　　处：《临床肝胆病杂志》2022年第6期1416-1419,共4页Journal of Clinical Hepatology

基　　金：河南省中医药科学研究专项课题(20-21ZY1011)。

摘　　要：原发性胆汁性胆管炎(PBC)是自身免疫性肝病之一,多数患者早期无明显临床表现,出现症状已至中晚期,尽早明确诊断及评估预后是非常必要的。抗gp210抗体对于诊断PBC及预测疾病进展有重要价值,检测该抗体可以优化PBC评分系统。本文总结评述了抗gp210抗体在PBC中的产生机制及检测的具体价值。Primary biliary cholangitis(PBC)is one of the autoimmune liver diseases,and most patients have no obvious clinical manifesta-tions in the early stage and have reached the advanced stage when symptoms appear.Therefore,it is necessary to make a confirmed diagnosis and evaluate prognosis as early as possible.Anti-gp210 antibody is of great value in the diagnosis of PBC and the prediction of disease pro-gression,and the detection of anti-gp210 antibody can help to optimize the PBC scoring system.This article reviews the production mecha-nism and detection value of anti-gp210 antibody in PBC.

关 键 词：肝硬化 胆汁性 抗体 诊断 预后 

分 类 号：R575.7[医药卫生—消化系统]