LMO2蛋白表达在T淋巴母细胞淋巴瘤/急性淋巴细胞白血病与胸腺瘤鉴别诊断中的应用  

Application of LMO2 protein expression in the differential diagnosis of T lymphoblastic lymphoma/acute lymphocytic leukemia and thymoma

作　　者：张婷婷[1] 朱培培 毕珂 芮炜玮 李冰[3] 黄丹丹 刘玉婷 张灏杨 易祥华[1] 曾郁[1] ZHANG Tingting;ZHU Peipei;BI Ke;RUI Weiwei;LI Bing;HUANG Dandan;LIU Yuting;ZHANG Haoyang;YI Xianghua;ZENG Yu(Department of Pathology,Tongji Hospital of Tongji University,Shanghai 200065;Department of Pathology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200010;Department of Hematology,Tongji Hospital of Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院病理科,上海200065 [2]上海交通大学医学院附属瑞金医院病理科,上海200010 [3]同济大学附属同济医院血液科,上海200065

出　　处：《临床与病理杂志》2022年第5期1047-1054,共8页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81401882);同济大学“中央高校基本科研业务费专项资金”(22120170004);上海市同济医院临床研究培育项目[ITJ(QN)1907];上海市卫生和计划生育委员会青年项目(20174Y0110)。

摘　　要：目的:探讨LMO2蛋白免疫组织化学染色在T淋巴母细胞淋巴瘤/急性淋巴细胞白血病(T lymphoblastic lymphoma/acute lymphocytic leukaemia,T-LBL/ALL)与胸腺瘤鉴别诊断中的价值。方法:对34例T-LBL/ALL及38例胸腺瘤组织应用免疫组织化学EnVision两步法进行LMO2标记。结果:29例T-LBL/ALL肿瘤细胞LMO2染色阳性(29/34,阳性率85.3%),38例胸腺瘤(A型3例、A B型14例、B 1型10例、B 2型5例、B 3型4例、C型2例)肿瘤性T淋巴细胞LMO2均阴性。LMO2蛋白表达在T-LBL/ALL和胸腺瘤之间差异有统计学意义(P<0.001)。结论:LMO2可作为T-LBL/ALL与胸腺瘤鉴别诊断的标志物。Objective:To explore the value of immunohistochemical staining of LMO2 protein in the differential diagnosis of T-lymphoblastic lymphoma/acute lymphocytic leukemia(T-LBL/ALL)and thymoma.Methods:Thirty-four cases of T-LBL/ALL and 38 cases of thymoma were labeled with LMO2 using immunohistochemical EnVision two-step method.Results:Neoplastic cells of 29 cases of T-LBL/ALL were positive for LMO2 staining(29/34,positive rate 85.3%),however,neoplastic T lymphocytes of 38 cases of thymoma including 3 cases of type A,14 cases of type AB,10 cases of type B1,5 cases of type B2,4 cases of type B3,2 cases of type C were negative for LMO2 staining.The expression of LMO2 protein was significantly different between T-LBL/ALL and thymoma(P<0.001).Conclusion:LMO2 can be used as a marker for the differential diagnosis of T-LBL/ALL and thymoma.

关 键 词：淋巴瘤 淋巴母细胞淋巴瘤 急性淋巴细胞白血病 胸腺瘤 LMO2 诊断 鉴别 

分 类 号：R733[医药卫生—肿瘤]