Protective effects of female reproductive factors on gastric signetring cell carcinoma  

作　　者：Yang Li Yu-Xin Zhong Quan Xu Yan-Tao Tian 

机构地区：[1]Department of Pancreatic and Gastric Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《World Journal of Clinical Cases》2022年第16期5217-5229,共13页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No.82072734.

摘　　要：BACKGROUND The overall incidence of gastric cancer is higher in men than women worldwide.However,gastric signet-ring cell carcinoma(GSRC)is more frequently observed in younger female patients.AIM To analyze clinicopathological differences between sexes in GSRC,because of the limited evidence regarding association between sex-specific differences and survival.METHODS We reviewed medical records for 1431 patients who received treatment for GSRC at the Cancer Hospital,Chinese Academy of Medical Sciences between January 2011 and December 2018 and surveyed reproductive factors.Clinicopathological characteristics were compared between female and male patients.Cox multivariable model was used to compare the mortality risks of GSRC among men,menstrual women,and menopausal women.RESULTS Of 1431 patients,935 patients were male and 496 were female(181 menstrual and 315 menopausal).The 5-year overall survival in male,menstrual female and menopausal female groups was 65.6%,76.5% and 65%,respectively(P<0.01).Menstruation was found to be a protective factor(hazard ratio=0.58,95% confidence interval:0.42–0.82).CONCLUSION The mortality risk of GSRC in menstrual women was lower than that in men.This study identified the protective effects of female reproductive factors in GSRC.

关 键 词：Gastric carcinoma Signet-ring cell Female reproductive factor MENOPAUSE 

分 类 号：R735.2[医药卫生—肿瘤]