Reno protective role of amlodipine in patients with hypertensive chronic kidney disease  

作　　者：Georgi Abraham A Almeida Kumar Gaurav Mohammed Yunus Khan Usha Rani Patted Maithrayie Kumaresan 

机构地区：[1]Department of Nephrology,MGM Healthcare,Nelson Manickam Road,Aminjikarai,Chennai 6300028,India [2]PD Hinduja Hospital and Medical Research Center,Almeida,A(reprint author),PD Hinduja,Hinduja Clin,Dept Med,Nephrol Sect,2209 Veer Savarkar Marg,Bombay 400016,Maharashtra,Mumbai 400016,India [3]Medical Affairs,Dr.Reddys Labs,Hyderabad 500016,Telangana,India [4]Medical Affairs,Madras Medial Mission Hospital,Chennai 600037,India

出　　处：《World Journal of Nephrology》2022年第3期86-95,共10页世界肾病学杂志（英文版）

摘　　要：Chronic kidney disease(CKD)and hypertension(HTN)are closely associated with an overlapping and intermingled cause and effect relationship.Decline in renal functions are usually associated with a rise in blood pressure(BP),and prolonged elevations in BP hasten the progression of kidney function decline.Regulation of HTN by normalizing the BP in an individual,thereby slowing the progression of kidney disease and reducing the risk of cardiovascular disease,can be effectively achieved by the anti-hypertensive use of calcium channel blockers(CCBs).Use of dihydropyridine CCBs such as amlodipine(ALM)in patients with CKD is an attractive option not only for controlling BP but also for safely improving patient outcomes.Vast clinical experiences with its use as monotherapy and/or in combination with other anti-hypertensives in varied conditions have demonstrated its superior qualities in effectively managing HTN in patients with CKD with minimal adverse effects.In comparison to other counterparts,ALM displays robust reduction in risk of cardiovascular endpoints,particularly stroke,and in patients with renal impairment.ALM with its longer half-life displays effective BP control over 24-h,thereby reducing the progression of endstage-renal disease.In conclusion,compared to other classes of CCBs,ALM is an attractive choice for effectively managing HTN in CKD patients and improving the overall quality of life.

关 键 词：AMLODIPINE Chronic kidney disease HYPERTENSION End-stage-renal disease MONOTHERAPY Combination therapy 

分 类 号：R69[医药卫生—泌尿科学]