Castleman disease of the pancreas mimicking pancreatic malignancy on^(68)Ga-DOTATATE and 18F-fluorodeoxyglucose positron emission tomography/computed tomography:A case report  

作　　者：Sheng-Lu Liu Ming Luo Hao-Xian Gou Xiao-Li Yang Kai He 

机构地区：[1]Department of General Surgery(Hepatobiliary Surgery),The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [3]Academician(Expert)Workstation of Sichuan Province,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2022年第5期514-520,共7页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Castleman disease is an uncommon nonclonal lymphoproliferative disorder,which frequently mimics both benign and malignant abnormalities in several regions.Depending on the number of lymph nodes or regions involved,Castleman disease(CD)varies in diagnosis,treatment and prognosis.It rarely occurs in the pancreas alone without any distinct clinical feature and tends to be confused with pancreatic paraganglioma(PGL),neuroendocrine tumors(NETs),and primary tumors,thus impeding proper diagnosis and treatment.CASE SUMMARY A 28-year-old woman presented with a lesion on the neck of the pancreas,detected by ultrasound during a health examination.Physical examination and laboratory findings were normal.The mass showed hypervascularity on enhanced computed tomography(CT),significantly increased 18F-fluorodeoxyglucose uptake on positron emission tomography(PET)/CT,and slightly increased somatostatin receptor(SSTR)expression on^(68)Ga-DOTATATE PET/CT,suggesting no distant metastases and subdiagnoses such as pancreatic PGL,NET,or primary tumor.Intraoperative pathology suggested lymphatic hyperplasia,and only simple tumor resection was performed.The patient was diagnosed with the hyaline vascular variant of CD,which was confirmed by postoperative immunohistochemistry.The patient was discharged successfully,and no recurrence was observed on regular review.CONCLUSION High glucose uptake and slightly elevated SSTR expression are potentially new diagnostic features of CD of the pancreas.

关 键 词：Castleman disease Pancreatic malignancy Pancreatic neuroendocrine tumors Pancreatic paraganglioma Positron emission tomography Case report 

分 类 号：R735.9[医药卫生—肿瘤]