Concomitant dysregulation of androgen secretion and dysfunction of adipose tissue induced insulin resistance  

作　　者：Marwan SM Al-Nimer 

机构地区：[1]Department of Clinical Pharmacology and Therapeutics,College of Medicine,University of Diyala,Baqubah 32001,Diyala,Iraq

出　　处：《World Journal of Diabetes》2022年第5期417-419,共3页世界糖尿病杂志（英文版）（电子版）

摘　　要：Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders e.g.,polycystic ovary disease and idiopathic hirsutism.Possible external and/or internal triggers can produce such cellular dysfunction.There is evidence that sodium valproate acts as a trigger of cellular dysfunction and produces both hyperinsulinemia and hyperandrogenism.Therefore,the elimination of these triggers can help the patients to recover from hyperinsulinemia,insulin resistance and hyperandrogenism.

关 键 词：HYPERANDROGENISM HYPERINSULINISM Central triggers Polycystic ovary disease 

分 类 号：R711.75[医药卫生—妇产科学] R589[医药卫生—临床医学]