Microglandular hyperplasia-like mucinous adenocarcinoma of the endometrium: A rare case report  

作　　者：Helen J Trihia Efthymia Souka George Galanopoulos Kitty Pavlakis Loukas Karelis Alexandros Fotiou Ioannis Provatas 

机构地区：[1]Department of Pathology,‘Metaxas’Memorial Cancer Hospital,Piraeus 18537,Greece [2]Department of Pathology,National&Kapodistrian University of Athens,Athens 11527,Greece [3]Department of Pathology,‘IASO’General Maternity&Gynecological Clinic,Maroussi,Athens 15123,Greece [4]Department of Gynaecologic Oncology,‘Metaxas’Memorial Cancer Hospital,Piraeus 18537,Greece [5]Department of Pathology,Evangelismos District General Hospital,Athens 10676,Greece

出　　处：《World Journal of Obstetrics and Gynecology》2022年第2期8-16,共9页世界妇产科杂志

摘　　要：BACKGROUND Microglandular hyperplasia(MGH)is a proliferation of endocervical glands,related to estrogen stimulation,mainly occurring in the reproductive age group.The differential diagnosis includes endometrial adenocarcinoma with MGH-like pattern(MGA),a distinction that may be particularly problematic in curettage specimen.CASE SUMMARY A 57-year-old,postmenopausal woman was admitted in our hospital for surgical treatment.She had been diagnosed with a uterine leiomyoma,after complaints of irregular vaginal bleeding.She underwent dilatation and curettage(D&C)and subsequent total abdominal hysterectomy with bilateral salpingo-oophorectomy.D&C were compatible with MGA.Histologically,a proliferation of small glands,without intervening stroma,with mucin production,accumulation of neutrophils in the gland lumen and stroma,mild nuclear atypia and rare mitoses,were seen.In the hysterectomy specimen,the endometrium was thickened,but without apparent tumor formation.On microscopic examination,a residual similar adenocarcinoma was seen in the isthmus and more conventional-of endometrioid and mucinous type,in the rest of the endometrium.CONCLUSION MGH-like proliferation with mild cytologic atypia,detected in the endometrial curettage specimen of a postmenopausal woman,should alert pathologists for MGA of the endometrium.VIM,p16,PAX-2,CD10 and CD34 may help in the differential diagnosis.

关 键 词：Microglandular hyperplasia-like Microglandular-like adenocarcinoma ENDOMETRIUM CURETTAGE PITFALL 

分 类 号：R73[医药卫生—肿瘤]