CD8-positive indolent T-Cell lymphoproliferative disorder of the gastrointestinal tract:A case report and review of literature  

作　　者：Chun-Yan Weng Cheng Ye Yi-Hong Fan Bin Lv Chun-Li Zhang Meng Li 

机构地区：[1]Department of Gastroenterology,The First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang Province,China [2]Department of Gastroenterology,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang Province,China [3]Department of Pathology,The First Affiliated Hospital of Zhejiang Chinese Medicine University,Hangzhou 310006,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第15期4971-4984,共14页世界临床病例杂志

摘　　要：BACKGROUND Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract(ITLPDGI),a primary tumor forming in the gastrointestinal(GI)tract,represents a rarely diagnosed clonal T-cell disease with a protracted clinical course.CASE SUMMARY This report presented a 45-year-old male patient with a 6-year history of anal fistula and a more than 10-year history of recurrent diarrhea who was not correctly diagnosed until the occurrence of complications such as intestinal perforation.Postsurgical histopathological analysis,combined with hematoxylineosin staining,immunohistochemistry and TCRβ/γ clonal gene rearrangement test,confirmed the diagnosis of CD8+ITLPD-GI.CONCLUSION Individuals with this scarce lymphoma frequently show non-specific symptoms that are hard to recognize.So far,indolent CD8+ITLPD-GI has not been comprehensively examined.The current mini-review focused on evaluating indolent CD8+ITLPD-GI cases based on existing literature and discussing future directions for improved differential diagnosis,detection of genetic and epigenetic alterations,and therapeutic target identification.

关 键 词：Indolent T-cell lymphoproliferative disease Gastrointestinal tract Inflammatory bowel disease IMMUNOHISTOCHEMISTRY Case report 

分 类 号：R735[医药卫生—肿瘤]