Metaplastic breast cancer with chondrosarcomatous differentiation combined with concurrent bilateral breast cancer:A case report  

作　　者：Si-Yuan Yang Yang Li Jian-Yun Nie Shou-Tao Yang Xiao-Juan Yang Mao-Hua Wang Ji Zhang 

机构地区：[1]Department of Breast Surgery,The Third Affiliated Hospital of Kunming Medical University,Kunming 650118,Yunnan Province,China [2]Department of Digestive Medicine,The First Affiliated Hospital of Kunming Medical University,Kunming 650118,Yunnan Province,China

出　　处：《World Journal of Clinical Cases》2022年第15期5064-5071,共8页世界临床病例杂志

摘　　要：BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and mortality.CASE SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast mass.The patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical mastectomy.Postoperative pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right breast.As the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine treatment.Then the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable condition.However,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is sporadic.CONCLUSION Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus.

关 键 词：Metaplastic breast cancer Invasive ductal carcinoma CARCINOSARCOMA Chondrosarcoma differentiation Bilateral breast cancer Case report 

分 类 号：R737.9[医药卫生—肿瘤]