抗富亮氨酸胶质瘤失活蛋白1抗体相关性脑炎的影像学及免疫学分析  

Imaging and Immunological Analysis of Anti-leucine-rich Glioma Inactivation Protein-1 Antibody Positive Encephalitis

作　　者：梁贺 姜立刚 LIANG He;JIANG Ligang(Affiliated Hospital of Jilin Medicial College,Jilin 132013,China)

机构地区：[1]吉林医药学院附属医院,吉林吉林132013

出　　处：《北华大学学报（自然科学版）》2022年第2期234-236,共3页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(JJKH20200459KJ);吉林省卫生健康委科技创新项目(20172C03).

摘　　要：目的探讨抗富亮氨酸胶质瘤失活蛋白1(LGI1)抗体相关性脑炎的临床特征.方法对1例血清和脑脊液LGI1抗体检测(细胞转染法)双阳性的抗LGI1抗体相关性脑炎患者采用激素联合免疫球蛋白治疗,症状得到明显缓解;出院后继续服用小剂量甲泼尼龙联合吗替麦考酚酯片进行长程免疫治疗.结果随访6个月,患者仅遗留记忆力下降、面-臂肌张力障碍发作情况,不自主多动症状消失.结论抗LGI1抗体阳性相关性脑炎患者主要以精神行为异常、四肢不自主多动、面-臂肌张力障碍发作等为主要临床特征.早期免疫治疗与预后密切相关,早期积极治疗可阻止疾病进展、恶化,进而降低复发率.Objective To investigate the clinical characteristics of anti-leucine-rich glioma inactivating protein-1(LGI1)antibody-positive encephalitis.Method A case of anti-LGI1 antibody associated encephalitis with double positive detection of LGI1 antibody in serum and cerebrospinal fluid(cell transfection method)was treated with hormone combined with immunoglobulin.Results After follow-up for 6 months,the patients only had memory loss and attack of face arm dystonia.All move autonomously.Conclusion Anti-LGI1 antibody-encephalitis is mainly characterized by abnormal mental behavior,involuntary hyperactivity of limbs,attack of face arm dystonia and so on.Early immunotherapy is closely related to prognosis.Early active treatment can prevent disease progression,deterioration and reduce the recurrence rate.

关 键 词：脑炎 面-臂肌张力障碍发作 免疫疗法 

分 类 号：R74[医药卫生—神经病学与精神病学]