Gray zone lymphoma effectively treated with cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab chemotherapy:A case report  

作　　者：Nobumasa Hojo Makoto Nagasaki Yasuha Mihara 

机构地区：[1]Department of General Medicine,National Hospital Organization Hamada Medical Center,Hamada City 697-8511,Shimane,Japan [2]Department of Pathology,National Hospital Organization Hamada Medical Center,Hamada City 697-8511,Shimane,Japan [3]Clinical Resident,National Hospital Organization Hamada Medical Center,Hamada City 697-8511,Shimane,Japan

出　　处：《World Journal of Clinical Cases》2022年第17期5708-5716,共9页世界临床病例杂志

摘　　要：BACKGROUND B-cell lymphoma,unclassifiable,with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma(BCLu-DLBCL/cHL),also referred to as gray zone lymphoma(GZL),is known to share features with cHL and DLBCL.However,GZL is often difficult to diagnose.There is no consensus regarding the optimal therapeutic regimen.Most reported cases of GZL have been in Caucasian and Hispanic individuals,and its incidence is lower in African-American and Asian populations,including the Japanese population.CASE SUMMARY A 69-year-old female presented at our hospital with a growing mass on the right side of her neck.An elastic,soft mass measuring 9 cm×6 cm was palpable in the right cervical region.Laboratory analyses showed pancytopenia,increased serum lactate dehydrogenase levels,and markedly increased levels of soluble interleukin-2 receptor.Enhanced computed tomography(CT)and fluorodeoxyglucose positron emission tomography(PET)/CT revealed multiple lesions throughout her body.She was diagnosed with GZL based on the characteristic pathological findings,the immunophenotype[CD20+,PAX5+,OCT2+/BOB1(focal+),CD30+,CD15-],and the strong positive expression of neoplastic programmed cell death protein ligand 1(PD-L1)in her lymphoma cells.The lymphoma was stage IV according to the Lugano classification and high-risk according to the International Prognostic Index for aggressive non-Hodgkin lymphoma.The patient received cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab(R-CHOP)chemotherapy because the tumor cells were CD20+.She has remained in complete remission for 3 years.CONCLUSION GZL was diagnosed based on histopathology and immunophenotyping with ancillary PD-L1 positivity.R-CHOP chemotherapy was an effective treatment.

关 键 词：Classical Hodgkin lymphoma Diffuse large B-cell lymphoma Gray zone lymphoma Programmed cell death protein ligand 1 R-CHOP Case report 

分 类 号：R733.1[医药卫生—肿瘤]