米诺环素软膏联合奥硝唑治疗慢性牙周炎的效果及对HMGB_1、PGE_(2)及炎症因子的影响  

Effects of minocycline ointment combined with ornidazole in the treatment of chronic periodontitis and its effect on HMGB_1,PGE2 and inflammatory factors

作　　者：马双 马微 沈红燕 刘金艳 李晨 李金义 杨志伟[5] MA Shuang;MA Wei;SHEN Hongyan;LIU Jinyan;LI Chen;LI Jinyi;YANG Zhiwei(Yinchuan Stomatological Hospital,Yinchuan 750001,China;People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;The Third People′s Hospital of Yinchuan,Yinchuan 750011,China;Clinical laboratory,Traditional Chinese Medicine Hospital of Yinchuan,Yinchuan,750001,China;Department of Pathogen Biology and Immunology,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学附属银川市口腔医院,宁夏银川750002 [2]宁夏回族自治区人民医院,宁夏银川750002 [3]宁夏回族自治区第三人民医院,宁夏银川750011 [4]宁夏银川市中医院检验科,宁夏银川750001 [5]宁夏医科大学病原生物学与免疫学系,宁夏银川750004

出　　处：《宁夏医学杂志》2022年第5期428-431,共4页Ningxia Medical Journal

摘　　要：目的探讨米诺环素软膏联合奥硝唑治疗慢性牙周炎的效果及对高迁移率族蛋白B1(HMGB_1)、前列腺素E_(2)(PGE_(2))及炎症因子的影响。方法选择120例慢性牙周炎患者为研究对象,采用随机数表法分为观察组60例、对照组60例。对照组给予奥硝唑治疗,观察组在对照组治疗的基础上给予米诺环素软膏治疗,比较2组患者临床疗效、HMGB_1、PGE_(2)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)、菌斑指数(PLI)、牙齿松动度(TM)及龈沟出血指数(SBI)水平变化情况及不良反应发生情况。结果治疗后,2组总有效率比较差异有统计学意义(P<0.05);治疗前2组患者HMGB_1、PGE2水平比较差异无统计学意义,治疗后2组HMGB_1、PGE_(2)水平均降低,且观察组均低于对照组(P<0.05);治疗前2组患者炎症因子水平比较差异无统计学意义,治疗后2组TNF-α、IL-6及IL-1β水平均显著降低,且观察组低于对照组(P<0.05);治疗前2组患者牙周状况检查结果比较差异无统计学意义,治疗后2组PLI、TM及SBI水平均显著降低,且观察组低于对照组(P<0.05)。2组患者用药不良反应发生情况比较差异无统计学意义(P>0.05)。结论米诺环素软膏联合奥硝唑治疗慢性牙周炎效果显著,可有效改善患者HMGB_1、PGE2及炎症因子水平。Objective To study effect of minocycline ointment combined with ornidazole in the treatment of chronic periodontitis and its effect on High mobility group protein B1(HMGB_1),prostaglandin E_(2)(PGE_(2))and inflammatory factors.Methods 120 patients with chronic periodontitis were treated and the patients were divided into experimental group(n=60)and control group(n=60).The control group was treated with ornidazole,the experimental group was treated with minocycline ointment on the basis of the control group.Clinical efficacy,HMGB_1,PGE 2,TNF-α,IL-6,IL-1β,plaque index(PLI),tooth looseness(TM),gingival sulcus bleeding index(SBI)and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate between the two groups was significantly different(P<0.05);Before treatment,there was no significant difference in HMGB_1 and PGE 2 levels between two groups.After treatment,the levels of HMGB_1 and PGE 2 in observation group and control group were significantly decreased,and observation group was lower than those in control group(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors between two groups.After treatment,the levels of TNF-α,IL-6 and IL-1βin observation group and control group were significantly decreased,and observation group was lower than those in control group(P<0.05).Before treatment,there was no significant difference in periodontal status between two groups.After treatment,PLI,TM and SBI levels in observation group and control group were significantly decreased,and observation group was lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between two groups during treatment(P>0.05).Conclusion In the treatment of chronic periodontitis,minocycline ointment combined with ornidazole has a significant effect,which can effectively improve the levels of HMGB_1,PGE 2 and inflammatory factors.

关 键 词：慢性牙周炎 米诺环素软膏 奥硝唑 高迁移率族蛋白B1 前列腺素E2 炎症因子 

分 类 号：R781.42[医药卫生—口腔医学]