补肾活血方联合卡左双多巴缓释片对帕金森病患者血清脂联素、肿瘤坏死因子、白细胞介素-6水平及认知功能的影响  

Effect of Bushen Huoxue Prescription Combined with Carbidopa and Levodopa Sustained-Release Tablets on Levels of Adiponectin,TNF-α and IL-6 in Serum and Cognitive Function of Patients with Parkinson Disease

作　　者：赵军伟 郭燕可 ZHAO Junwei;GUO Yanke

机构地区：[1]许昌市人民医院神经内一科,河南许昌461000 [2]河南省中医院急诊科,河南郑州450002

出　　处：《新中医》2022年第8期72-76,共5页New Chinese Medicine

基　　金：河南省中医管理局项目(20-21ZY2205)。

摘　　要：目的:观察补肾活血方联合卡左双多巴缓释片对帕金森病(PD)患者认知功能及其血清脂联素、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)水平的影响。方法:选取72例PD患者按随机数字表法分治疗1组和治疗2组各36例,另选取50例同期体检健康人群为对照组。治疗1组采用卡左双多巴缓释片治疗,治疗2组采用卡左双多巴缓释片联合补肾活血方治疗。比较2组治疗前后血清脂联素、TNF-α及IL-6水平变化,并采用简易智力状态检查量表(MMSE)评估患者认知功能。结果:治疗前,治疗1组与治疗2组脂联素水平均较对照组低,2组TNF-α、IL-6水平均较对照组高,差异均有统计学意义(P<0.05);治疗1组与治疗2组脂联素、TNF-α、IL-6水平比较,差异均无统计学意义(P>0.05)。治疗后,治疗1组、治疗2组脂联素水平均较治疗前升高,2组TNF-α、IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);治疗2组脂联素水平高于治疗1组,TNF-α、IL-6水平低于治疗1组,差异均有统计学意义(P<0.05)。治疗前,治疗1组与治疗2组MMSE量表中即时记忆力、语言能力、定向力、注意力和计算力、延迟回忆力评分及总分比较,差异无统计学意义(P>0.05);治疗后,2组MMSE量表各项评分及总分均较治疗前升高(P<0.05),且治疗2组各项评分及总分升高较治疗1组更显著(P<0.05)。结论:补肾活血方联合卡左双多巴缓释片能够明显提高PD患者血清脂联素水平,降低炎症反应,提高患者认知功能,疗效优于单用卡左双多巴缓释片治疗。Objective: To observe the effect of Bushen Huoxue prescription combined with carbidopa and levodopa sustained-release tablets on levels of adiponectin, tumor necrosis factor-α(TNF-α) and Interleukin(IL-6) in serum and cognitive function of patients with Parkinson disease(PD). Methods:A total of 72 cases of PD patients were selected and divided into the treatment group 1 and the treatment group 2 according to the random number table method,with 36 cases in each group;50 people who had physical examinations in the same period and received healthy results were selected and included in the control group. The treatment group 1 was treated with carbidopa and levodopa sustained-release tablets,and the treatment group 2 was treated with carbidopa and levodopa sustained-release tablets and Bushen Huoxue prescription.Changes in levels of adiponectin,TNF-α and IL-6 in serum in the two groups before and after treatment were compared.The cognitive function was evaluated by Mini-Mental State Examination(MMSE). Results: Before treatment, levels of adiponectin in the treatment group 1 and the treatment group 2 were decreased when compared with those in the control group, and levels of TNF-α and IL-6 were increased, differences being significant(P<0.05);there was no significant difference being found in the comparison of levels of adiponectin,TNF-α and IL-6 between the treatment group 1 and the treatment group 2(P>0.05). After treatment,levels of adiponectin in the treatment group 1 and the treatment group 2 were increased when compared with those before treatment,and levels of TNF-α and IL-6 were decreased,the difference being significant(P<0.05);level of adiponectin in the treatment group 2 was higher than that in the treatment group 1,and levels of TNF-α and IL-6 were lower than those in the treatment group 1, differences being significant(P<0.05). Before treatment,when compared scores of immediate memory,language,orientation,attention and calculation,and delayed recall as well as the total scores in MMSE scale between

关 键 词：帕金森病 卡左双多巴缓释片 补肾活血方 脂联素 肿瘤坏死因子-α 白细胞介素-6 认知功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]