ABC转运蛋白及其相关的多药抗性研究现状  

Research status of ATP-binding cassette transporters and related multidrug resistance

作　　者：孙铭优 吴照晨 王斌 王婷婷 李雪明 宋佳露 刘鹏飞 刘西莉 Sun Mingyou;Wu Zhaochen;Wang Bin;Wang Tingting;Li Xueming;Song Jialu;Liu Pengfei;Liu Xili(Key Laboratory of Pest Monitoring and Green Management,Ministry of Agriculture and Rural Affairs,College of Plant Protection,China Agricultural University,Beijing 100193,China;State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Sinochem Agrochemicals Research and Development Company Limited,Shenyang 110021,Liaoning Province,China)

机构地区：[1]中国农业大学植物保护学院,农业农村部作物有害生物监测与绿色防控重点实验室,北京100193 [2]沈阳中化农药化工研发有限公司,新农药创制与开发国家重点实验室,沈阳110021

出　　处：《植物保护学报》2022年第1期374-382,共9页Journal of Plant Protection

基　　金：国家自然科学基金(31772192)。

摘　　要：ABC(ATP-binding cassette)转运蛋白是一类家族庞大、功能多样的跨膜转运蛋白,其广泛存在于原核和真核生物的各类细胞器中,负责多种物质的跨膜转运,从而调节生物体的一系列生命活动。近年来,越来越多ABC转运蛋白的种类及功能被报道,但是ABC蛋白家族的潜在成员以及功能仍然值得进一步探究和挖掘。该文对不同物种中ABC转运蛋白数量、结构域、功能、研究方法以及其参与调控病原菌多药抗性的研究现状进行综述,并对植物病原菌多药抗性的治理等进行展望。ATP-binding cassette(ABC)transporters are a large family of transmembrane proteins with diverse functions,they are widely present in various organelles of prokaryotic and eukaryotic organisms and are responsible for the transmembrane transport of various substances,thereby regulating a series of life activities.In recent years,more and more types and functions of ABC transporters have been reported,however,the potential members and functions of the ABC protein family are still worthy of further exploration.The number,domains,functions,and research methods of ABC transporters in different species are reviewed,as well as their participation in regulating the multidrug resistance of plant pathogens are discussed.Besides,the management strategies for multidrug resistance of plant pathogens are also prospected.

关 键 词：ABC转运蛋白 蛋白结构 基因功能 多药抗性 

分 类 号：S432.4[农业科学—植物病理学]