女性血清sIL-6R、JAK2、STAT3水平与乳腺癌发生的关联性  

Correlation between serum sIL-6R,JAK2,STAT3 levels and breast cancer in women

作　　者：霍斌亮[1] 田有伏 祝旭龙 李程[1] Huo Binliang;Tian Youfu;Zhu Xulong;Li Cheng(Department of Oncology, Shaanxi Provincial People's Hospital, Shaanxi Province,Xi'an 710068, China)

机构地区：[1]陕西省人民医院肿瘤外科,西安710068

出　　处：《疑难病杂志》2022年第6期576-581,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：陕西省自然科学基础研究计划项目(2020JQ-936)。

摘　　要：目的评估女性血清可溶性白介素-6受体(sIL-6R)、Junus激酶蛋白(JAK)2、信号转导及转录激活因子(STAT)3水平与乳腺癌发生的关联性。方法选取2019年1月—2021年9月陕西省人民医院肿瘤外科诊治女性乳腺癌患者112例为观察组,选取同期医院健康体检女性112例为健康对照组。比较2组血清sIL-6R、JAK2、STAT3水平,采用Logistic回归模型分析乳腺癌发病的影响因素,经相对超危险度比(RERI)、归因比(AP)、交互作用指数(S)分析血清sIL-6R、JAK2、STAT3在乳腺癌发生中的交互作用。结果观察组血清sIL-6R、JAK2、STAT3水平高于对照组(t/P=18.947、16.283、10.894,P均<0.001);经Logistic回归模型分析显示,血清sIL-6R、JAK2、STAT3水平高为发生乳腺癌的独立危险因素[OR(95%CI)=3.842(2.358~6.259)、4.783(3.002~7.620)、3.876(1.804~8.329)];血清sIL-6R、JAK2、STAT3对乳腺癌的发病存在正向交互作用,三者均高表达时乳腺癌的发病风险是其均低表达时的64.600倍,三者同时高表达致乳腺癌发病风险是其他未知因子(OR=1)的7.604倍(RERI=7.604),协同效应为三者单独存在产生效应之和的1.223倍(S=1.223),在sIL-6R、JAK2、STAT3共存的乳腺癌发病风险中,有11.77%(AP=11.77%)是由三者交互作用引起的。结论女性血清sIL-6R、JAK2、STAT3的高表达与乳腺癌的发生密切相关,且三者高表达在乳腺癌的发病中有交互作用,有助于早期识别高危患者。Objective To evaluate the correlation between the levels of serum soluble interleukin-6 receptor(sIL-6R),Junus kinase protein 2(JAK2),signal transducer and activator of transcription 3(STAT3)and breast cancer in women.Methods From January 2019 to September 2021,112 female breast cancer patients who were diagnosed and treated by the Department of Oncology,Shaanxi Provincial People's Hospital were selected as the observation group,and 112 healthy women who underwent physical examination in the hospital during the same period were selected as the healthy control group.The levels of serum sIL-6R,JAK2,and STAT3 between the two groups were compared,and logistic regression model was used to analyze the influencing factors of breast cancer incidence.The interaction of JAK2 and STAT3 in breast cancer.Results The serum levels of sIL-6R,JAK2 and STAT3 in the observation group were higher than those in the control group(t/P=18.947,16.283,10.894,all P<0.001).Logistic regression model analysis showed that high levels of serum sIL-6R,JAK2 and STAT3 were independent risk factors for breast cancer[OR(95%CI)=3.842(2.358-6.259),4.783(3.002-7.620),3.876(1.804-8.329)].sIL-6R,JAK2,and STAT3 have a positive interaction on the incidence of breast cancer.The risk of breast cancer when all three are highly expressed is 64.600 times higher than when they are all low.The risk of breast cancer caused by high expression of the three is unknown.factor(OR=1)was 7.604 times(RERI=7.604),and the synergistic effect was 1.223 times the sum of the three effects alone(S=1.223).In the risk of breast cancer with the coexistence of sIL-6R,JAK2 and STAT3,there are 11.77%(API=11.77%)was caused by the interaction of the three.Conclusion The high expression of serum sIL-6R,JAK2,and STAT3 in women is closely related to the occurrence of breast cancer,and the high expression of the three has an interaction in the occurrence of breast cancer,which is helpful for early identification of high-risk patients.

关 键 词：乳腺癌 可溶性白介素-6受体 Junus激酶蛋白2 信号转导及转录激活因子3 关联性 女性 

分 类 号：R737.9[医药卫生—肿瘤]