酪氨酸激酶Fyn的生物学特性及其在肿瘤发生发展中的作用  

Biological Characteristics of Tyrosine Kinase Fyn and Its Function in Tumorigenesis and Tumor Progression

作　　者：李昂 浦昕元 姜语 张海辉 黄建 许伟榕 LI Ang;PU Xinyuan;JIANG Yu;ZHANG Haihui;HUANG Jian;XU Weirong(Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Center for Laboratory Instruction in Basic Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院生物化学与分子细胞生物学系,上海200025 [2]上海交通大学医学院基础医学实验教学中心,上海200025

出　　处：《中国细胞生物学学报》2022年第3期451-459,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82073043);上海交通大学医学院临床医学八年制RBL项目/第十四届大学生创新性实验项目(批准号:1420Y008)资助的课题。

摘　　要：酪氨酸激酶Fyn是Src家族激酶的成员之一,其持续活化被认为与肿瘤细胞的代谢、增殖和迁移有密切的联系。Fyn在肿瘤的发生发展中起着重要的调控作用。该文从结构特征、相关信号通路及基本生理功能等方面阐述了Fyn的生物学特性,总结了近年来围绕Fyn展开的研究,重点归纳了Fyn在脑胶质瘤、血液系统肿瘤、胰腺癌等肿瘤中发挥的促癌作用,并在此基础上提出了肿瘤靶向治疗可能的研究方向。Fyn kinase,a member of SFKs(Src family kinases),may be closely related to metabolism,proliferation and migration of tumor cells,functioning as an important regulator in tumorigenesis.In this review,the fundamental properties,the related signal pathway and the basic physiological functions of Fyn are discussed to illuminate the molecular characteristics of Fyn.Furthermore,current research progress of Fyn and its promoting effects in the oncogenesis of glioma,hematologic neoplasms,and pancreatic neoplasms are specially summarized.Based on that,this review proposes the directions for the subsequent study of tumor targeted therapy.

关 键 词：FYN Src家族激酶 整合素 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]