经颅磁刺激联合奥氮平在流浪精神病患者中的应用效果  被引量:2

Application effects of transcranial magnetic stimulation combined with Olanzapine on mental symptoms and sleep disorders in vagrant patients

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作  者:张利平 郑玉玲 莫映雪 ZHANG Liping;ZHENG Yuling;MO Yingxue(Medical Treatment Area,Dongguan Seventh People′s Hospital,Guangdong Province,Dongguan523000,China)

机构地区:[1]广东省东莞市第七人民医院医疗救治区,广东东莞523000

出  处:《中国当代医药》2022年第16期133-135,共3页China Modern Medicine

摘  要:目的探讨经颅磁刺激(TMS)联合奥氮平在流浪精神病患者中的应用效果。方法选择2019年1月至2021年9月东莞市第七人民医院收治的76例流浪精神病患者作为研究对象,按随机数字表法分为对照组(38例)与观察组(38例)。对照组给予奥氮平治疗,观察组在此基础上联合TMS治疗,共治疗4周。比较两组患者精神症状[阳性症状和阴性症状量表(PANSS)评分]、睡眠质量[匹兹堡睡眠质量量表(PSQI)]、临床疗效及不良反应。结果两组患者治疗前的PANSS、PSQI评分比较,差异无统计学意义(P>0.05);两组患者治疗后的阴性症状、阳性症状、一般精神病理评分及PANSS总分、PSQI评分低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的阴性症状、阳性症状、一般精神病理评分及PANSS总分、PSQI评分低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率(92.11%)高于对照组(63.16%),差异有统计学意义(P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论TMS联合奥氮平应用于流浪精神病患者治疗中,能有效改善其精神症状及睡眠障碍,疗效确切,安全性高。Objective To investigate the effect of transcranial magnetic stimulation(TMS)combined with Olanzapine in vagrant psychiatric patients.Methods A total of 76 patients with vagrant psychosis treated in Dongguan Seventh People′s Hospital from January 2019 to September 2021 were selected as the study subjects,and they were divided into control group(38 cases)and observation group(38 cases)by random number table method.The control group was treated with Olanzapine and the observation group was treated with TMS for 4 weeks.Mental symptoms(positive and negative symptom scale[PANSS]scores),sleep quality(Pittsburgh sleep quality scale[PSQI])and adverse reactions were compared between the two groups.Results There was no significant difference in PANSS and PSQI scores between the two groups before treatment(P>0.05).The negative symptoms,positive symptoms,general psychopathological score,PANSS total score and PSQI score of the two groups after treatment were lower than those before treatment,with statistical significances(P<0.05).The negative symptoms,positive symptoms,general psychopathological score,PANSS total score and PSQI score in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group(92.11%)was higher than that of the control group(63.16%),with statistical significance(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion TMS combined with Olanzapine in the treatment of vagrant psychosis can effectively improve their mental symptoms and sleep disorders.It has definite curative effect and high safety.

关 键 词:精神病 经颅磁刺激 奥氮平 精神症状 睡眠障碍 

分 类 号:R749[医药卫生—神经病学与精神病学]

 

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