自身免疫性肝病抗体谱检测在自身免疫性肝病诊断中的应用价值  

Application value of autoimmune liver disease antibody spectrum detection in the diagnosis of autoimmune liver disease

作　　者：曹蒙 关锐 CAO Meng;GUAN Rui(Hanzhong People's Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市人民医院,陕西汉中723000

出　　处：《临床医学研究与实践》2022年第17期140-143,共4页Clinical Research and Practice

摘　　要：目的研究自身免疫性肝病抗体谱检测在自身免疫性肝病诊断中的应用价值。方法选择2017年7月至2021年2月在本院进行检查的219例肝功能异常患者、116例健康体检者为研究对象,将其分别纳入疾病组和正常组。所有研究对象均接受肝功能检查、自身免疫性肝病抗体谱检测。比较各组的检测结果,包括肝功能指标(AST、ALT、ALP、GGT)、自身免疫性肝病抗体谱(AMA-M2、ANA、LKM-1、LC-1、gp-210、SP100、SLA/LP抗体阳性率及总阳性率);比较不同亚型自身免疫性肝炎患者的抗体谱检测结果。结果疾病组不同疾病类型患者的AST、ALT、ALP、GGT水平均高于正常组,差异具有统计学意义(P<0.05)。自身免疫性肝炎组的AMA-M2、ANA、LKM-1、LC-1、gp-210、SP100、SLA/LP阳性率及总阳性率均高于正常组、原发性硬化性胆管炎组,差异具有统计学意义(P<0.05);原发性胆汁性胆管炎组与自身免疫性肝炎组的ANA、LKM-1、LC-1、gp-210、SP100、SLA/LP阳性率及总阳性率比较,差异具有统计学意义(P<0.05)。自身免疫性肝炎患者中,Ⅱ亚型的LKM-1阳性率高于Ⅰ、Ⅲ亚型,差异具有统计学意义(P<0.05);Ⅰ亚型的LC-1阳性率高于Ⅱ、Ⅲ亚型,差异具有统计学意义(P<0.05);Ⅲ亚型的gp-210、SLA/LP阳性率高于Ⅰ、Ⅱ亚型,差异具有统计学意义(P<0.05)。结论通过检测自身免疫性肝病抗体谱能够为自身免疫性肝病的鉴别诊断提供参考。Objective To study the application value of autoimmune liver disease antibody spectrum detection in the diagnosis of autoimmune liver disease.Methods A total of 219 patients with abnormal liver function and 116 healthy people examined in our hospital from July 2017 to February 2021 were selected as the research objects and included in disease group and normal group respectively.All research objects received liver function test and autoimmune liver disease antibody spectrum detection.The detection results of each group were compared,including liver function indexes(AST,ALT,ALP,GGT),autoimmune liver disease antibody spectrum(AMA-M2,ANA,LKM-1,LC-1,gp-210,SP100,SLA/LP antibody positive rate and total positive rate);the detection results of antibody spectrum in patients with different subtypes of autoimmune hepatitis were compared.Results The levels of AST,ALT,ALP and GGT in patients with different disease types in the disease group were higher than those in the normal group,and the differences were statistically significant(P<0.05).The positive rates of AMA-M2,ANA,LKM-1,LC-1,gp-210,SP100,SLA/LP and total positive rate in autoimmune hepatitis group were higher than those in the normal group and primary sclerosing cholangitis group,and the differences were statistically significant(P<0.05);there were significant differences in the positive rates of ANA,LKM-1,LC-1,gp-210,SP100,SLA/LP and the total positive rate between primary biliary cholangitis group and the autoimmune hepatitis group(P<0.05).In patients with autoimmune hepatitis,the positive rate of LKM-1 in subtypeⅡwas higher than that in subtypesⅠandⅢ,and the difference was statistically significant(P<0.05);the positive rate of LC-1 in subtype I was higher than that in subtypesⅡandⅢ,and the difference was statistically significant(P<0.05);the positive rates of gp-210 and SLA/LP in subtypeⅢwere higher than those in subtypesⅠandⅡ,and the differences were statistically significant(P<0.05).Conclusion The detection of autoimmune liver disease antibody sp

关 键 词：自身免疫性肝病 自身免疫性肝病抗体谱 肝功能检查 自身免疫性肝炎 原发性硬化性胆管炎 原发性胆汁性胆管炎 

分 类 号：R57[医药卫生—消化系统]