Sucrose-free hawthorn leathers formulated with fructooligosaccharides and xylooligosaccharides ameliorate high-fat diet induced inflammation, glucose and lipid metabolism in liver of mice  

作　　者：Tao Li Lihan Xu Qiaojuan Yan Jun Liu Zhengqiang Jiang 

机构地区：[1]Key Laboratory of Food Bioengineering(China National Light Industry),College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China [2]Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Engineering,China Agricultural University,Beijing 100083,China

出　　处：《Food Science and Human Wellness》2022年第4期1064-1075,共12页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China (31630096)。

摘　　要：High sucrose content in traditional hawthorn leathers limits the potential consumption, particularly for elders and diabetics. In this study, sucrose-free hawthorn leathers were formulated with 75% fructooligosaccharides(FOS) and 25% xylooligosaccharides(XOS)(HLF75), which exhibited comparable morphology and sensory properties to the traditional ones. Then, the anti-obesity activity of HLF75 was investigated using high-fat diet(HFD) fed C57BL/6J mice. Comparing with traditional hawthorn leathers, HLF75 supplementation in HFD significantly decreased the levels of blood glucose and serum lipid. The histomorphologies of liver and subcutaneous fat tissues were ameliorated by HLF75, as well as the down-regulated m RNA expression levels of IL-1β, Nos2 and Cox-2 in the liver. M oreover, the protein levels of M y D88 and NF-κB in the liver were suppressed by HLF75 treatment with decreased F4/80-positive macrophage number. Ho wever, the expression levels of PI3K, phosphorylated-AKT(Thr308), and phosphorylated-m TOR(Ser2448) proteins related to glucose metabolism were increased in the liver. Moreover, fat synthesis-related gene expression in HLF75-fed mice was suppressed while expressions of lipolysis genes were improved. Thus, HLF75 supplementation alleviated HFD-induced obesity through the alleviation of inflammation and restoration of the disturbed glucose and lipid metabolism. Functional oligosaccharides could be effective sucrose substitutes in hawthorn leathers and enable their potential utilization as functional foods.

关 键 词：Hawthorn leathers Functional oligosaccharides Inflammatory responses Glucose and lipid metabolism ANTI-OBESITY 

分 类 号：TS209[轻工技术与工程—食品科学] TS201.4[轻工技术与工程—食品科学与工程]