Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action  

作　　者：Wenping Tang Jianfeng Zhan Shiming Li Yue Liu Chi-Tang Ho 

机构地区：[1]Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization,Huanggang Normal University,Huanggang 438000,China [2]Department of Food Science,Rutgers University,New Brunswick 08901,USA [3]Department of Chemical Biology,Rutgers University,Piscataway 08901,USA

出　　处：《Food Science and Human Wellness》2022年第5期1177-1182,共6页食品科学与人类健康（英文）

基　　金：supported by Hubei Science and Technology Plan key Project,Hubei Province,China(2019ABA100)。

摘　　要：In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated complications.Food is one of the key factors in preventing and combating diseases such as diabetes.Both as a food and an herbal medicine,Polygonum multiflorum(PM)has been used as an anti-aging tonic,for hair darkening in traditional Chinese medicine for several centuries.The recent research effort of PM has been focused on antioxidant,anti-ageing and anti-tumor properties.In the present study,we utilized the traditional processing of harvested raw PM,and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract(PME).PME(0.075%)was given to diabetic mice(KK CgAy/J)in drinking water and after 7 weeks,PME-treated mice had significantly lower glucose levels than mice in the diabetic control group(P<0.01).The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintainingβ-cell function.

关 键 词：DIABETES Stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment 

分 类 号：TS201.4[轻工技术与工程—食品科学]