血浆纤维蛋白原、aPTT及D二聚体水平在甲状腺功能亢进患者的检测价值  

Detection Value of Plasma Fibrinogen,aPTT and D-dimer Levels in patients with Hyperthyroidism

作　　者：邢蒙 王小梅 XING Meng;WANG Xiao-mei(Department of Endocrinology,Xi'an High-tech Hospital,Xi'an,710065,China;Department of Laboratory,The Second Hospital of Hanbin District,Ankang 725000,China)

机构地区：[1]西安高新医院内分泌科,西安710065 [2]安康市汉滨区第二医院检验科,安康725000

出　　处：《血栓与止血学》2022年第3期911-913,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的:探讨血浆纤维蛋白原(Fbg)、活化部分凝血活酶时间(aPTT)及D二聚体(D-D)水平在甲状腺功能亢进患者的检测价值。方法选取2018年1月~2021年1月在我院收治的甲状腺功能亢进患者80例(甲亢组),另选取同期甲状腺功能正常的体检患者80例作为对照组(正常组)。采用凝固法检测纤维蛋白原(Fbg)和活化部分凝血活酶时间(aPTT)水平,采用免疫比浊法检测D二聚体(D-D)水平,比较两组Fbg、aPTT和D-D水平,采用受试者工作曲线(ROC)分析血浆Fbg、aPTT和D-D对甲亢患者诊断价值。结果甲亢组Fbg和D-D高于正常组,aPTT低于正常组(P<0.05);血浆Fbg、aPTT和D-D预测甲亢的诊断价值分别为0.698、0.771和0.757(P<0.05),联合诊断价值更高(AUC=0.847,95%CI为0.787~0.907,P<0.05)。结论甲亢患者Fbg和D-D水平较高,aPTT水平较低,临床医师可通过联合检测以上指标提高甲亢早期诊断的临床价值。Objective To investigate the value of plasma fibrinogen(Fbg),activated partial thromboplastin time(aPTT)and D-dimer(D-D)levels in patients with hyperthyroidism.Methods 80 patients with hyperthyroidism treated in our hospital from January 2018 to January 2021(hyperthyroidism group)and 80 physical examination patients with normal thyroid function in the same period were selected as the control group(normal group).The levels of fibrinogen(Fbg)and activated partial thromboplastin time(aPTT)were detected by coagulation method,and the levels of D-dimer(D-D)were detected by immunoturbidimetry.The levels of Fbg,aPTT and D-D in the two groups were compared.The diagnostic value of plasma Fbg,aPTT and D-D in patients with hyperthyroidism was analyzed by receiver operating curve(ROC).Results Fbg and D-D in hyperthyroidism group were higher than those in normal group,and aPTT was lower than those in normal group(P<0.05);The diagnostic values of plasma Fbg,aPTT and D-D in predicting hyperthyroidism were 0.698,0.771 and 0.757 respectively(P<0.05),and the combined diagnostic value was higher(AUC=0.847,95%CI 0.787~0.907,P<0.05).Conclusion The levels of Fbg and D-D in patients with hyperthyroidism are higher and the level of aPTT is lower.Clinicians can improve the clinical value of early diagnosis of hyperthyroidism by jointly detecting the above indexes.

关 键 词：甲状腺功能亢进 纤维蛋白原 活化部分凝血活酶时间 D二聚体 受试者工作曲线 

分 类 号：R736.1[医药卫生—肿瘤]