表面微孔及内部管网结构促进聚醚醚酮与软组织结合的体内实验  

Digital design and manufacture of internal structure promotes the binding of polyetheretherketone specimen with soft tissue:An in vivo study

作　　者：冯晓珂 白石柱[2] 赵铱民[3] FENG Xiaoke;BAI Shizhu;ZHAO Yimin(Department of Prosthodontics,Tianjin Stomatological Hospital,School of Medicine,Nankai University,China,3000041;State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology,Department of Digital Center,School of Stomatology,The Fourth Military Medical University,Xi'an;State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi'an)

机构地区：[1]天津市口腔医院修复一科,南开大学医学院,300041 [2]第四军医大学口腔医学院数字化中心,军事口腔医学国家重点实验室,国家口腔疾病临床研究中心,陕西省口腔医学重点实验室 [3]第四军医大学口腔医学院修复教研室,军事口腔医学国家重点实验室,国家口腔疾病临床研究中心,陕西省口腔医学重点实验室

出　　处：《实用口腔医学杂志》2022年第3期300-304,共5页Journal of Practical Stomatology

基　　金：天津市口腔医院科技基金-青年项目(编号:2021KLQN02);天津市卫生健康委员会科技项目-青年项目(编号:TJWJ2021QN067)。

摘　　要：目的:探究数字化技术在辅助设计制作的管、网结构在促进聚醚醚酮(PEEK)与软组织结合中的应用。方法:将设计的管、网结构打印出树脂代型,用热压铸制备出相应的PEEK试件。用浓硫酸酸蚀PEEK,并通过表面形貌检测及新西兰大白兔皮下移植来评估这种具有表面微孔及内部管、网结构的PEEK与软组织的结合能力。结果:成功制备出具有内部管、网结构的PEEK。酸蚀后PEEK呈白垩色,接触角变小。植入动物皮下后,酸蚀的PEEK较未酸蚀的PEEK与软组织结合的更好;有管、网结构的PEEK较没有管、网结构的PEEK与软组织结合的更好。结论:结合数字化设计制作的内部管、网结构与表面酸蚀微孔组合的PEEK能更好的和软组织的结合。Objective:To observe the effects of digital technology in promoting the combination of polyether ether ketone(PEEK)specimen with soft tissue.Methods:The PEEK specimens with tube and network structure were designed and printed into resin model,and then the corresponding PEEK specimens were prepared by injection-molding technology.Then the specimens were etched with concentrated sulfuric acid,and the binding ability of the specimens with surface micropores and internal tube and network structure with soft tissues in New Zealand white rabbits was observed by histological examination.Results:PEEK with internal tube and network structure was successfully prepared.PEEK showed chalky color and smaller contact angle after acid etching.After implantation,acid etched PEEK specimens could bind to soft tissue better than non-etched ones.PEEK with tube and network structure showed better combination with soft tissue than that without tube and network structure.Conclusion:PEEK fabricated by digital design with internal tube and network structure and the surface with acid etched micropores can better combine with soft tissue in vivo.

关 键 词：数字化设计 3D打印 热压铸 聚醚醚酮 软组织 

分 类 号：R783.1[医药卫生—口腔医学]