鳞状细胞癌抗原及白介素-38在宫颈癌患者外周血的表达水平及诊断价值  

Expression level and diagnostic value of squamous cell carcinoma antigen and interleukin-38 in peripheral blood of patients with cervical cancer

作　　者：覃彩凤 杨进琼[1] 许雪珍 QIN Caifeng;YANG Jinqiong;XU Xuezhen(Department of Gynecology,Gaozhou People′s Hospital,Guangdong Province,Gaozhou525200,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Ji′nan University,Guangdong Province,Guangzhou510000,China)

机构地区：[1]广东省高州市人民医院妇科二区,广东高州525200 [2]暨南大学附属第一医院妇产科,广东广州510000

出　　处：《中国当代医药》2022年第15期23-26,F0003,共5页China Modern Medicine

摘　　要：目的探究鳞状细胞癌抗原(SCC)及白介素-38(IL-38)在宫颈癌患者的外周血的表达水平及诊断价值。方法选取2019年2月至2021年5月高州市人民医院收治的52例宫颈癌患者作为研究组,并选取同期高州市人民医院收治的50例子宫上皮内瘤变患者作为瘤变组,另选取同期于高州市人民医院体检的50例正常健康女性作为对照组。在入院时检测并比较三组研究对象的SCC、IL-38表达水平;比较不同病理因素的患者IL-38、SCC的表达水平;治疗结束后检测研究组患者的IL-38及SCC,并与入院时的检测结果进行比较,最后采用受试者工作特征(ROC)曲线评价各指标的诊断效能。结果研究组IL-38及SCC表达水平均高于瘤变组及对照组,且瘤变组两项指标也均高于对照组,差异有统计学意义(P<0.05);治疗后研究组的IL-38及SCC表达水平均低于治疗前,差异有统计学意义(P<0.05)。Ⅲ/Ⅳ分期的IL-38、SCC表达水平高于Ⅰ/Ⅱ分期,高分化程度的IL-38表达水平高于低、中分化程度,中分化程度的IL-38表达水平高于低分化程度,差异有统计学意义(P<0.05)。ROC曲线显示,血清IL-38及SCC诊断宫颈癌的曲线下面积(AUC)为0.729、0.748,而联合诊断的AUC为0.826,且此时敏感度为82.32%,特异度为76.37%,均高于单个指标。结论SCC、IL-38与宫颈癌的发病及病情进展相关,将两者联合作为诊断指标可提高宫颈癌诊断的准确率,对该病有较大的临床治疗指导意义和诊断价值,值得推广应用。Objective To investigate the expression level and diagnostic value of squamous cell carcinoma antigen(SCC)and interleukin-38(IL-38)in peripheral blood of patients with cervical cancer.Methods A total of 52 cases of cervical cancer patients admitted to Gaozhou People′s Hospital in February 2019 to May 2021 were selected as the study group,50 patients with uterine intraepithelial neoplasia admitted to Gaozhou People′s Hospital in the same period were selected as the neoplastic group,and 50 normal healthy women examined in Gaozhou People′s Hospital in the same period were selected as the control group.The expression levels of SCC and IL-38 in the three groups were detected and compared on admission.The expression levels of IL-38 and SCC in patients with different pathological factors were compared.After treatment,IL-38 and SCC of patients in the study group were detected and compared with the results on admission.Finally,the diagnostic efficacy of each index was evaluated by receiver operating characteristic(ROC)curve.Results The expression levels of IL-38 and SCC in the study group were higher than those in the neoplastic group and control group,the differences were statistically significant(P<0.05).The two indexes in the neoplastic group were also higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,IL-38 and SCC expression levels of the study group were lower than those before treatment,the differences were statistically significant(P<0.05).IL-38,SCC expression levels ofⅢ/Ⅳstage were higher than those of theⅠ/Ⅱstage,IL-38 expression level of high degree of differentiation was higher than that of low,medium degree of differentiation,IL-38 expression level of medium degree of differentiation was higher than that of low degree of differentiation,the differences were statistically significant(P<0.05).ROC curve showed that the area under curve(AUC)of serum IL-38 and SCC in the diagnosis of cervical cancer was 0.729 and 0.748,while the AUC of combin

关 键 词：鳞状细胞癌抗原 白介素-38 宫颈癌 诊断 诊断价值 

分 类 号：R730.43[医药卫生—肿瘤]