骨髓增殖性肿瘤异质性与克隆演化  

Heterogeneity and Clonal Evolution of Myeloproliferative Neoplasms

作　　者：宋濬哲 袁佳佳 周圆 SONG Junzhe;YUAN Jiajia;ZHOU Yuan(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)

机构地区：[1]中国医学科学院血液病医院(中国医学科学院血液学研究所),实验血液学国家重点实验室,国家血液系统疾病临床医学研究中心,细胞生态海河实验室,天津300020

出　　处：《中国细胞生物学学报》2022年第1期93-100,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81770128、81970120、81890990);国家重点研发计划(批准号:2020YFE0203000)资助的课题。

摘　　要：费城染色体阴性骨髓增殖性肿瘤(myeloproliferative neoplasms,MPNs)是一组以成熟髓系细胞增生为主要特征的慢性血液肿瘤。MPN在遗传、临床表型和肿瘤细胞代谢等多个方面都具有显著的异质性,其克隆演化过程受到造血干细胞突变、骨髓炎症环境和免疫功能失调等多种内、外因素的影响。该文拟从异质性和克隆演化的角度综述MPN发生发展及其调控机制的最新研究进展。MPNs(myeloproliferative neoplasms)are a group of chronic hematological neoplasms characterized by the proliferation of mature myeloid cells.Patients with MPNs show a significantly greater degree of heterogeneity in genetics,clinical phenotype,and cancer metabolism.The clonal evolutionary process is regulated by various intrinsic and extrinsic factors including mutations in HSCs(hematopoietic stem cells),inflammatory bone marrow microenvironment and immune dysfunction.Here,recent advances in the pathogenesis of MPN from the perspective of heterogeneity and clonal evolution are summarized.

关 键 词：骨髓增殖性肿瘤 发病机制 异质性 克隆演化 

分 类 号：R733.3[医药卫生—肿瘤]