活性氧捕获材料的研究进展  

Advances in the Scavenging Materials for Reactive Oxygen Species

作　　者：赵晋源 张乾[1] 王坚 张琦 李恒[2] 杜亚平 Zhao Jinyuan;Zhang Qian;Wang Jian;Zhang Qi;Li Heng;Du Yaping(School of Science,Xi’an University of Technology,Xi'an,710054;Department of Anorectal Surgery,Xi’an Central Hospital,Xi'an,710003;Tianjin Key Lab for Rare Earth Materials and Applications,Center for Rare Earth and Inorganic Functional Materials,School of Materials Science and Engineering&National Institute for Advanced Materials,Nankai University,Tianjin,300350)

机构地区：[1]西安理工大学理学院,西安710054 [2]西安市中心医院肛肠外科,西安710003 [3]南开大学材料科学与工程学院&国家新材料研究院天津市稀土材料与应用重点实验室南开大学稀土与无机功能材料研究中心,天津300350

出　　处：《化学学报》2022年第4期570-580,共11页Acta Chimica Sinica

基　　金：国家自然科学基金(No.21971117);京津冀协同创新项目(No.19YFSLQY00030);天津市自然科学基金杰青(No.20JCJQJC00130);天津市自然科学基金重点项目(No.20JCZDJC00650);天津市稀土材料与应用重点实验室(No.ZB19500202);111项目(No.B18030)资助。

摘　　要：生命从呼吸中获得氧气,氧气再进一步在线粒体中将糖类等氧化得到能量,提供给生命过程使用.然而在氧化过程中,会生成高度活泼的活性氧.当体内控制失衡的时候,它的浓度会大大增加,发生氧化应激,对机体产生不可逆的破坏,引起衰老、肿瘤、心血管以及神经性疾病等.抵抗活性氧的核心物质是抗氧化物,它的存在使氧化应激受到控制,从而保护机体免遭伤害.本文对国内外近年来在活性氧自由基捕获方面的研究进行系统的综述,通过梳理,提出研究的金字塔型三级结构.设计抗氧化物大分子与无机纳米粒子复合的纳米杂化自由基捕获器可以一方面解决无机纳米粒子的毒性问题,另一方面还可以赋予纳米粒子额外的功能.期待这篇综述文章能为改性纳米粒子捕捉活性氧提供一些有益思路,为功能高分子材料与杂化纳米技术在生物医学领域的探索提供借鉴.Life obtains oxygen from breathing,which further oxidizes carbohydrates and acquires energy in mitochondria to support life processes.However,in the process of oxidation,highly reactive oxygen species(ROS)will be generated.When the human bodies lose its control on ROS,its concentration will be greatly increased,causing oxidative stress and irreversible damage to the body,thus resulting in aging,tumor,cardiovascular and neurological diseases,etc.Antioxidants are the core substances that resist ROS,and control the oxidative stress and protect the body from being damaged.In this paper,we briefly review the research progress on the scavenging materials for ROS in recent years,and see a pyramidic structure with three levels on the design of related scavenging materials.The design of nano-hybrid free radical scavenger might not only solve the toxicity problem of inorganic nanoparticles,but also afford the system with the additional functions.Hopefully,this review may enlighten some clues for the people working in the area to design highly functional ROS scavenger materials with high performances.

关 键 词：活性氧 抗氧化物 氧化应激 纳米粒子 毒性 

分 类 号：R318.08[医药卫生—生物医学工程] TB34[医药卫生—基础医学]