异甘草酸镁联合腺苷蛋氨酸治疗肝衰竭患者疗效与价值  

Curative effect and value of magnesium isoglycyrrhizinate combined with S-adenosylmethionine in the treatment of patients with liver failure

作　　者：韩一梅 陈志娟[1] 孙斌[1] 张珺 王成[1] 张辉[1] HAN Yimei;CHEN Zhijuan;SUN Bin;ZHANG Jun;WANG Cheng;ZHANG Hui(Hanzhong Central Hospital,Hanzhong 723000,Shanxi,China)

机构地区：[1]汉中市中心医院,陕西汉中723000

出　　处：《西部医学》2022年第6期908-912,共5页Medical Journal of West China

基　　金：陕西省卫生计生科研基金项目(2016E035)。

摘　　要：目的探讨异甘草酸镁(MGIG)联合腺苷蛋氨酸(SAMe)治疗肝衰竭患者疗效与价值。方法选择本院2015年2月~2020年9月诊治的肝衰竭患者129例,随机数字表法分为对照组(64例)和研究组(65例),对照组给予MGIG联合还原型谷胱甘肽治疗,研究组给予MGIG联合SAMe治疗。比较两组患者治疗前后血浆总胆红素(TBil)、丙氨酸氨基转移酶(ALT)、白蛋白(ALb)、凝血酶原指标和炎症因子水平变化,比较两组并发症发生率,并评估其疗效。结果研究组患者治疗总有效率显著高于对照组(P<0.05);治疗前两组患者血浆TBil、ALT、ALb水平比较差异无统计学意义(P>0.05),治疗后研究组血浆TBil水平低于对照组,ALT、ALb水平高于对照组(均P<0.05);治疗前两组患者凝血酶原指标比较差异无统计学意义(P>0.05),治疗后研究组凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)水平低于对照组,凝血酶原活动度(PTA)水平高于对照组(均P<0.05);治疗前两组患者炎症因子水平比较差异无统计学意义(P>0.05),治疗后研究组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平显著低于对照组,IL-10水平显著高于对照组(P<0.05);两组患者肝性脑病、电解质紊乱、自发性腹膜炎以及上消化道出血发生率比较差异无统计学意义(P>0.05),但研究组患者腹水发生率显著低于对照组(P<0.05)。结论SAMe联合MGIG在肝衰竭患者治疗中具有较高的应用价值,可改善肝功能和凝血功能,减轻炎症反应,减少并发症,其联合应用疗效优于单一用药。Objective To study the curative effect and value of magnesium isoglycyrrhizinate(MGIG)combined with S-adenosylmethionine(SAMe)in the treatment of patients with liver failure.Methods 129 patients with liver failure diagnosed and treated in the hospital were selected for the study between February 2015 and September 2020.The patients were divided into control group(64 cases)and study group(65 cases)by random number table method.The patients in the control group were treated with MGIG combined with reduced glutathione,while the patients in the study group were treated with MGIG combined with SAMe.Changes in the levels of plasma total bilirubin(TBil),alanine aminotransferase(ALT),albumin(ALb),prothrombin indicators and inflammatory factors before and after treatment,and the incidence of complications were compared between the two groups.Curative effect was evaluated.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).Before treatment,there were no significant differences in the levels of plasma TBil,ALT,and ALb between the two groups.After treatment,the plasma TBil level in the study group was lower than that in the control group,while the levels of ALT and ALb were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in prothrombin indicators between the two groups.After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the study group were shorter than those in the control group,and the prothrombin activity(PTA)was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in the levels of inflammatory factors between the two groups.After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the study group were significantly lower than those in the control group,and the IL-10 level was significantly higher than that in the control group(P<0.05).The incidences of hepatic encephalopathy,ele

关 键 词：异甘草酸镁 腺苷蛋氨酸 肝衰竭 总胆红素 丙氨酸氨基转移酶 白蛋白 

分 类 号：R575.3[医药卫生—消化系统]