胃癌化疗配合康莱特注射液治疗对免疫细胞活性的影响  

Effect of Kanglaite Injection on immune cell activity in patients with gastric cancer chemotherapy

作　　者：傅强 胡立业 吴建程 肖勋立 张媛 FU Qiang;HU Liye;WU Jiancheng;XIAO Xunli;ZHANG Yuan(Department of Pharmacy,Affiliated Hospital of Jinggangshan University,Jiangxi Province,Ji′an343000,China)

机构地区：[1]井冈山大学附属医院药剂科,江西吉安343000

出　　处：《中国当代医药》2022年第13期110-112,116,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2021B648)。

摘　　要：目的探讨康莱特注射液辅助治疗对胃癌化疗患者免疫细胞活性的影响。方法选取2019年10月至2021年8月井冈山大学附属医院收治的84例中晚期胃癌患者为研究对象,按照随机数字表法分为两组,每组各42例。对照组采用常规多西他赛联合顺铂化疗方案治疗,治疗组在对照组的基础上应用康莱特注射液治疗,两组患者均在治疗2个周期时评估疗效。比较治疗前、治疗2个周期时两组患者的临床疗效;于治疗前、治疗2个周期时,比较两组患者免疫功能水平[T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))];记录治疗期间两组患者不良反应发生情况。结果治疗组治疗2个周期时疾病控制率高于对照组,整体治疗效果优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异无统计学意义(P>0.05);治疗2个周期时,两组患者CD8^(+)均高于治疗前,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均低于治疗前,但治疗组CD8^(+)低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05)。治疗组治疗期间恶心呕吐、骨髓抑制发生率低于对照组,差异有统计学意义(P<0.05)。结论康莱特注射液辅助用于胃癌化疗患者中,可增强患者免疫功能,提高临床疗效,减少恶心呕吐及骨髓抑制的发生。Objective To investigate the effect of Kanglaite Injection on immune cell activity in patients with gastric cancer chemotherapy.Methods A total of 84 patients with advanced gastric cancer admitted to the Affiliated Hospital of Jinggangshan University from October 2019 to August 2021 were selected as the research objects.They were divided into two groups by random number table method,with 42 cases in each group.The control group was treated with conventional Docetaxel combined with Cisplatin chemotherapy,and the treatment group was treated with Kanglaite Injection on the basis of the control group.The curative effect was evaluated during 2 cycles of treatment in both groups.Compared the clinical efficacy of the two groups before treatment and after 2 cycles of treatment,compare the immune function levels of the two groups(T lymphocyte subsets[CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)])before treatment and during 2 cycles of treatment,record the occurrence of side effects in the two groups during treatment.Results The disease control rate of patients in the treatment group was higher than that of the control group during the 2 cycles of treatment,and the overall treatment effect was better than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)between two groups before treatment(P>0.05).The CD8^(+)of two groups during the 2 cycles of treatment were higher than those before treatment,and the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were lower than those before treatment,but the CD8^(+)of the treatment group was lower than that of the control group,and the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher than those of the control group,the differences were statistically significant(P<0.05).During treatment period,the incidence of nausea,vomiting and bone marrow suppression of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Kanglaite Injection

关 键 词：胃癌 化疗 多西他赛 顺铂 康莱特注射液 免疫功能 

分 类 号：R735.2[医药卫生—肿瘤]