淤浆法制备高黏度羧甲基纤维素钠的工艺研究  

Study on preparation of sodium carboxymethyl cellulose with high viscosity by slurry process

作　　者：王思远 苏慧[1] 徐岩[1] 徐世一 WANG Si-yuan;SU Hui;XU Yan;XU Shi-yi(School of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Experimental Training Center,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学实验实训中心,黑龙江哈尔滨150040

出　　处：《应用化工》2022年第4期1020-1023,共4页Applied Chemical Industry

基　　金：黑龙江省自然科学基金联合引导项目(LH2020H096);黑龙江省教育科学规划重点课题(GJB1421297)。

摘　　要：为替代高成本的海藻酸钠,以精制棉纤维素为原料采用淤浆法合成高黏度高取代度的羧甲基纤维素钠(CMC)。通过研究不同溶剂体系、物料比例、NaOH溶液浓度、碱化时间、醚化温度和时间等制备工艺条件对CMC产品指标的影响,确定了最佳制备工艺条件为:以异丙醇(75%)-叔丁醇(25%)为溶剂,棉碱醚投料质量比例为1∶1.5∶1.5,45%NaOH溶液碱化1 h,75℃醚化1.5 h。在该工艺条件的基础下成功制备黏度>1000 mPa·s,DS>1.4,酸粘比>0.5的高黏度高取代度CMC产品,为更高效的淤浆法制备工艺改良提供了参考。To replace the high cost of sodium alginate,sodium carboxymethyl cellulose(CMC)with high viscosity and degree of substitution was synthesized from refined cotton cellulose by slurry method.Comparing different preparation process conditions on the effect of CMC product index,such as diverse solvent system,material ratio,concentration of NaOH solution,time for alkalization,temperature and time for etherification,the optimum conditions were as follow:with isopropyl alcohol(75%)-tert-butyl alcohol(25%)as solvent,the mass ratio of cotton,sodium hydroxide and chloroacetic acid was 1∶1.5∶1.5.The alkalization reaction was conducted with 45%NaOH solution for 1 h,and the etherification reaction was conducted for 1.5 h at 7℃.Under selected conditions,CMC with high viscosity and degree of substitution(viscosity>1000 mPa·s,DS>1.4 and acid viscosity ratio>0.5)were successfully prepared,which provided a reference for the improvement of more efficient slurry preparation process.

关 键 词：纤维 淤浆法 羧甲基纤维素钠 高黏度 高取代度 制备工艺 

分 类 号：TQ35[化学工程]