乳腺MRI背景实质强化与乳腺癌分子分型的相关性  

Correlation between background parenchymal enhancement of breast MRI and molecular subtyping of breast cancer

作　　者：茅依玲 汪登斌[1] 王丽君[1] 陈艳 何江波 MAO Yi-ling;WANG Deng-bin;WANG Li-jun(Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 201900)

机构地区：[1]上海交通大学医学院附属新华医院,上海200092 [2]宝山区中西医结合医院,上海201900

出　　处：《放射学实践》2022年第6期710-714,共5页Radiologic Practice

基　　金：上海市卫计委智慧医疗专项研究项目(2018ZHYL0108);上海市“科技创新行动计划”生物医药科技支撑专项(21S31905000)。

摘　　要：目的:探讨乳腺磁共振背景实质强化(BPE)与乳腺癌分子分型的相关性。方法:回顾性搜集术前行乳腺MRI检查且经病理结果证实为浸润性导管癌患者80例,分析BPE水平(a轻微;b轻度;c中度;d显著)与乳腺癌患者临床特征及病理分子分型的相关性。BPE与乳腺癌患者年龄及绝经状态之间的相关性采用Spearman相关性检验。BPE在不同乳腺癌分子分型间的差异采用卡方检验。结果:BPE与年龄呈负相关(R=-0.258,P=0.021)。BPE水平与月经状态差异有统计学意义(P=0.011),BPE水平为显著的患者多为绝经前,占58/80,BPE水平为轻微者多为绝经后患者,占65/80。80例乳腺癌中Luminal A 23例(23/80),Luminal B 30例(30/80),Her2过表达17例(17/80),三阴性10例(10/80);ER阳性53例(53/80),PR阳性43例(43/80),HER2阳性30例(30/80);Ki-67高表达48例(48/80)。卡方检验显示BPE在不同分子分型(Luminal A、Luminal B、Her2过表达、三阴性)间差异无统计学意义,P=0.392;BPE与ER、PR、HER2、Ki-67间差异亦无统计学意义(P值分别为0.259、0.067、0.138、0.869)。结论:BPE水平与年龄负相关,绝经后BPE多为轻微型。BPE水平与乳腺癌分子分型差异无统计学意义,尚不能认为BPE对预测乳腺癌分子分型有预测价值。Objective:The aim of this study was to investigate the correlation between background parenchymal enhancement(BPE)of breast MRI and molecular subtyping of breast cancer.Methods:Eighty women with invasive breast cancer confirmed by pathology,who had preoperative breast MRIs,were retrospectively recruited.We analyzed the correlation among BPE levels(a,minimal;b,mild;c,moderate;d,marked)and the patients'clinical characteristics and pathological molecular classification.Spearman's correlation test was used to analyze the correlation between BPE level and breast cancer patients’age.And chi-square test was used to test different BPE levels between menopausal and non-menopausal patients.The chi-square test was also used to test the difference of BPE level in different molecular types of breast cancer.Results:BPE was negatively correlated with age(R=-0.258,P=0.021).The difference of BPE levels in menopausal and non-menopausal patients was statistically significant(P=0.011).Most patients with d-type BPE were premenopausal,accounting for 58/80;while those with a-type BPE were almost postmenopausal,accounting for 65/80.Among 80 cases,there were 23(23/80)Luminal A cases,30(30/80)Luminal B cases,17(17/80)Her2 overexpression cases,10(10/80)triple-negative cases,and 53(53/80)ER-positive cases,43(43/80)PR positive ones,30(30/80)HER2 positive ones,48(48/80)Ki-67 highly expressed cases.Chi-square test showed that there was no significant correlation between BPE level and different molecular types(Luminal A,Luminal B,Her2 overexpression,triple negative)(P=0.347).And,there was no statistical correlation between BPE level and ER,PR,HER2 or Ki-67,P values were 0.29,0.363,0.61,and 0.43 respectively.Conclusion:BPE is negatively correlated with age.Postmenopausal patients are almost a-type BPE.There was no significant statistically correlation between BPE and molecular subtyping of breast cancer.It is not yet considered that BPE has a predictive effect on molecular subtyping of breast cancer.

关 键 词：乳腺肿瘤 磁共振成像 背景实质强化 分子分型 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]