NDPK/nm23 基因在原发性胆囊癌中的表达及临床意义  

Expression and clinical significance of NDPK/nm23 in primary gallbladder carcinoma

作　　者：钟碧波[1] 钟芳 寇继光[1] ZHONG Bi-bo;ZHONG Fang;KOU Ji-guang(Department of Gastroenterology,Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology,Xiaogan Hubei 432000,China;Department of Endocrinology,Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology,Xiaogan Hubei 432000,China)

机构地区：[1]武汉科技大学附属孝感市中心医院消化内科,湖北孝感432000 [2]武汉科技大学附属孝感市中心医院内分泌科,湖北孝感432000

出　　处：《临床和实验医学杂志》2022年第10期1038-1042,共5页Journal of Clinical and Experimental Medicine

摘　　要：目的探究核苷二磷酸激酶(NDPK)/nm23基因在原发性胆囊癌(PGBC)中的表达情况及临床意义。方法回顾性选取2016年2月至2021年5月在武汉科技大学附属孝感市中心医院接受治疗的PGBC患者124例,计为PGBC组;同时选取60例胆囊腺瘤性息肉患者进行对比,计为胆囊腺瘤性息肉组。检测各组NDPK/nm23基因表达情况以及基因表达意义。结果PGBC组织中的NDPK/nm23基因表达阳性率为31.45%,低于胆囊腺瘤性组织(50.00%),差异有统计学意义(P<0.05)。不同性别、年龄、临床症状(黄疸、胆绞痛)以及血清胆红素增高情况患者的NDPK/nm23基因表达情况差异无统计学意义(P>0.05),存在PGBC家族病史、由于胆囊息肉样变导致PGBC、存在右上腹痛患者的NDPK/nm23基因表达阳性率较低,差异均有统计学意义(P<0.05)。病情发展相关指标分析显示,Nevin分期越高或分化程度越低,患者NDPK/nm23基因表达阳性率越低,同时存在淋巴转移的PGBC患者基因表达阳性率较低,差异均有统计学意义(P<0.05)。Logistic回归分析显示,PGBC家族病史、Nevin分期≥Ⅲ期、高分化以及淋巴转移与NDPK/nm23基因表达存在显著联系(OR=0.702,95%CI:0.515-0.957;OR=0.448,95%CI:0.375-0.536;OR=0.327,95%CI:0.267-0.400;OR=0.393,95%CI:0.235-0.657)。结论原发性患者的NDPK/nm23基因表达情况影响其病情发展的影响,临床中可根据机体NDPK/nm23基因检测以协助评估PGBC患者的疾病发展阶段,制定更完善的救治计划,改善患者预后。Objective The aim of this study was to investigate the expression and clinical significance of nucleoside diphosphate kinase(NDPK)/nm23 in primary gallbladder carcinoma(GBC).Methods A total of 124 patients with PGBC treated in Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology were retrospectively selected between February 2016 and May 2021.Meanwhile,60 patients with adenomatous polyps of the gallbladder were selected as controls.The expression of NDPK/nm23 in each group was detected,and its significance was analyzed.Results The positive rate of NDPK/nm23 expression in PGBC tissue was 31.45%,which was lower than that in adenomatous polyps of the gallbladder(50.00%),the difference was statistically significant(P<0.05).There was no significant difference in NDPK/nm23 expression between patients with different gender,age,clinical symptoms(jaundice,biliary colic)and increases in serum bilirubin(P>0.05).The positive rate of NDPK/nm23 expression was lower in patients with family history of PGBC,with PGBC caused by gallbladder polypoid degeneration,and right upper abdominal pain(P<0.05).Analysis of indicators related to disease development found that the higher the Nevin stage or the lower the differentiation degree,the lower the positive rate of NDPK/nm23 expression(P<0.05).The positive rate of gene expression was lower in patients with PGBC and lymphatic metastasis(P<0.05).Logistic regression analysis showed that family history of PGBC,Nevin stage≥Ⅲ,high differentiation,and lymphatic metastasis were significantly associated with NDPK/nm23 expression(OR=0.702,95%CI:0.515-0.957;OR=0.448,95%CI:0.375-0.536;OR=0.327,95%CI:0.267-0.400;OR=0.393,95%CI:0.235-0.657).Conclusion The expression of NDPK/nm23 affects the development of PGBC.In clinical practice,the detection of NDPK/nm23 can assist in assessing the stage of PGBC,thereby helping formulate a more complete treatment plan and improving the prognosis.

关 键 词：原发性胆囊癌 核苷二磷酸激酶/nm23基因 病情进展 临床表现 

分 类 号：R735.8[医药卫生—肿瘤]