牙髓干细胞多项分化潜能的研究及应用进展  

Research on Multipotent Differentiation of Human Dental Pulp Stem Cells and Its Application Progress

作　　者：夏亮[1,2,3] 江文欣[4] 邹多宏 XIA Liang;JIANG Wenxin;ZOU Duohong(Department of Oral and Cranio-maxillofacial Surgery,the Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Department of Oral Surgery,the Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Shanghai Key Laboratory of Stomatology,Shanghai Jiao Tong University School of Stomatology/National Center of Stomatology/National Clinical Research Center for Oral Diseases,Shanghai 200011,China;Department of Dentistry,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颅颌面科,上海200011 [2]上海交通大学医学院附属第九人民医院口腔外科,上海200011 [3]上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011 [4]上海交通大学医学院附属仁济医院口腔科,上海200011

出　　处：《医学综述》2022年第11期2086-2091,共6页Medical Recapitulate

基　　金：国家自然科学基金(31870969);上海交通大学医学院“双百人”人才计划(20191816);上海交通大学医学院附属第九人民医院医学研究培育基金(九院基础研究助推计划JYZZ114)。

摘　　要：再生医学通过利用干细胞分化为特定细胞类型的能力来替代和恢复组织功能。干细胞是具有自我更新和无限克隆能力的原始细胞,参与组织发育、维持稳态及组织缺损修复等多种生理过程。牙髓内含有丰富的牙源性成体干细胞即牙髓干细胞(DPSC),其具有增殖活跃和自我更新能力。DPSC具有很强的多谱系分化能力,包括成骨分化、牙源性分化、成脂分化、成软骨分化、神经源性分化等,目前已经广泛应用于组织工程及再生医学领域。Regenerative medicine has the potential to replace and restore tissue function by utilizing the ability of stem cells to differentiate into specific cell types.Stem cells are primitive cells with self-renewal and unlimited cloning ability,which participate in a variety of physiological processes such as tissue development,maintaining homeostasis and tissue defect repair.There are abundant adult stem cells in dental pulp,namely dental pulp stem cell(DPSC),which have the ability of active proliferation,self-renewal.DPSC have multi lineage differentiation,including osteogenic differentiation,odontogenic differentiation,adipogenic differentiation,chondrogenic differentiation,neurogenic differentiation and so on,and have been widely used in tissue engineering and regenerative medicine.

关 键 词：再生医学 干细胞 牙髓干细胞 组织工程 

分 类 号：R781.3[医药卫生—口腔医学]