脑胶质瘤免疫微环境中细胞因子的研究进展  

Research Progress of Cytokines in Immune Microenvironment of Glioma

作　　者：林鸿溢 冯洋 龙妮娅 出良钊 LIN Hongyi;FENG Yang;LONG Niya;CHU Liangzhao(Department of Neurosurgery,the Affiliated Hospital of Guizhou Medical University,Guizhou 550004,China;Department of Surgery,Guizhou Medical University,Guizhou 550004,China)

机构地区：[1]贵州医科大学附属医院神经外科,贵阳550004 [2]贵州医科大学外科学教研室,贵阳550004

出　　处：《医学综述》2022年第11期2134-2138,共5页Medical Recapitulate

基　　金：贵州省科技计划项目(黔科合〔2016〕支撑2905)。

摘　　要：脑胶质瘤是人类中枢神经系统中最常见的原发性恶性肿瘤,目前手术切除以及术后联合放化疗等传统治疗改善患者远期生存率的效果并不太理想。免疫微环境对胶质瘤的发生发展起关键作用,而作为免疫微环境的重要组成部分的细胞因子(白细胞介素、基质细胞衍生因子-1、转化生长因子-β等)是调控微环境免疫抑制性的重要一环。因此,探究胶质瘤中存在的相关细胞因子对免疫微环境的影响是进一步了解肿瘤免疫微环境的关键,并有望为延长脑胶质瘤患者生命,甚至治愈脑胶质瘤提供新的方法及思路。Glioma is the most common primary malignant tumor in the human central nervous system,and the current conventional treatments such as surgical resection and postoperative radiotherapy are not very satisfactory in improving the long-term survival of the patients.The immune microenvironment plays a key role in the development of glioma.As an important part of immune microenvironment,cytokines(interleukin,stromal cell-derived factor-1,transforming growth factor-β,etc)play an important role in regulating immune suppression in microenvironment.Therefore,exploring the influence of relevant cytokines in glioma on its immune microenvironment is the key to further understanding of the immune microenvironment of tumors,which is expected to provide new approaches and ideas for prolonging the lives of the glioma patients and even curing glioma.

关 键 词：脑胶质瘤 免疫微环境 细胞因子 白细胞介素 基质细胞衍生因子-1 转化生长因子-Β 集落刺激因子 血管内皮生长因子 

分 类 号：R739.41[医药卫生—肿瘤]