正常人睡眠期脑磁图顶尖波的特点-同步脑磁图-脑电图对比研究  

Characteristics of MEG vertex waves in normal subjects during sleep-a simultaneous MEG-EEG study

作　　者：任洁钏[1] 任国平 杨春兰[2] 杨春清 李恭斐 孙越乾 齐婧 徐娜 乔慧[3] 王群[1,4] Ren Jiechuan;Ren Guoping;Yang Chunlan;Yang Chunqing;Li Gongfei;Sun Yueqian;Qi Jing;Xu Na;Qiao Hui;Wang Qun(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心,北京100070 [2]北京工业大学环境与生命学部 [3]首都医科大学,北京市神经外科研究所 [4]国家神经系统疾病临床医学研究中心,北京脑重大疾病研究院

出　　处：《脑与神经疾病杂志》2022年第5期265-270,共6页Journal of Brain and Nervous Diseases

基　　金：国家自然科学基金青年基金(81601126,81801280);首都卫生发展科研专项(首发2016-1-2011,首发2020-1-2013);北京自然科学基金重点项目(Z200024)。

摘　　要：目的研究正常人睡眠期中顶尖波在同步记录的脑磁图(MEG)和脑电图(EEG)中的关系,描述总结MEG中顶尖波的特点。方法同步采集5例健康被试睡眠期MEG与EEG波形,总结EEG顶尖波出现时对应的MEG顶尖波的波形特点,并用临床常用的等效电流偶极子方法进行MEG的溯源定位。结果5例健康被试中,共记录到164个EEG顶尖波,其中142个同期MEG有相应波形变化,MEG顶尖波总体出现率为86.59%。MEG顶尖波的形态、时限差异性较大,与EEG具备不同的相位关系。通过偶极子溯源分析,MEG顶尖波主要定位于中线结构较深的区域,以及散在分布于双侧脑叶的中央区附近。结论MEG中出现的顶尖波有区别于EEG顶尖波的特点。临床MEG读图工作中,根据这些特点正确识别顶尖波十分重要。Objective We tried to correlate sleep vertex waves seen in electroencephalography(EEG)with those in magnetoencephalography(MEG),and describe the features of vertex waves in MEG.Methods We recorded simultaneous MEG and EEG signals during sleep in 5 healthy subjects,and summarized the features of MEG vertex waves at the same time when EEG vertex waves appeared.Then we used equivalent current dipole model to locate the vertex waves seen in MEG.Results 164 vertex waves in EEG were recorded in total,in which 142 have the correlates of MEG vertex waves.The appearance rate of MEG vertex wave is 86.59%for all.There was a great variability in the morphology and duration of MEG vertex waves,and MEG vertex waves and EEG vertex waves showed variable phase relationships.The MEG vertex dipoles located mainly in the midline structures,as well as bilateral central regions.Conclusions Vertex waves in MEG have characteristics different from the traditional features of EEG vertex waves.It is important to recognize those vertex waves in MEG clinical practice.

关 键 词：顶尖波 脑磁图 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]