增塑剂DEHP神经毒性作用及机制的研究进展  

Research Progress on Neurotoxic Effects and Mechanism of Plasticizer DEHP

作　　者：王婷 高星梅 郭会彩[1,2] 刘诣 王磊[3] Wang Ting;Gao Xingmei;Guo Huicai;Liu Yi;Wang Lei(School of Public Health,Hebei Medical University,Shijiazhuang 050017,China;Hebei Key Laboratory of Environment and Human Health,Shijiazhuang 050017,China;School of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学公共卫生学院,石家庄050017 [2]河北省环境与人群健康重点实验室,石家庄050017 [3]河北医科大学药学院,石家庄050017

出　　处：《生态毒理学报》2022年第2期33-42,共10页Asian Journal of Ecotoxicology

基　　金：河北省自然科学基金资助项目(H2020206584);河北省教育厅重点项目(ZD20190440)。

摘　　要：近年来,增塑剂邻苯二甲酸二(2-乙基己)酯(di-(2-ethylhexyl)phthalate,DEHP)的神经毒性作用越来越受到人们的关注。DEHP可通过多种途径进入脑组织并作用于中枢神经系统,导致各种损伤。因此,笔者系统阐述DEHP进入脑组织的途径、神经毒性作用表现及其机制,为今后深入研究DEHP的健康效应及分子机制,制定更为合理的、针对不同暴露人群的安全限值和暴露限值提供理论参考。In recent years,the neurotoxicity of the plasticizer di-(2-ethylhexyl)phthalate(DEHP)has attracted more and more attention.DEHP can enter the brain tissue through a variety of routes and act on the central nervous system,causing various injuries.Therefore,this review systematically elucidates the ways that DEHP enters the brain tissue,its neurotoxic effects and underlying mechanisms so as to provide recommendations for future research on the health effects and molecular mechanisms of DEHP,and also to provide references to develop more reasonable safety and exposure limits for different exposed groups.

关 键 词：邻苯二甲酸二(2-乙基己)酯 神经毒性 阿尔茨海默症 

分 类 号：X171.5[环境科学与工程—环境科学]