Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara  

作　　者：LI Yu-Peng YANG Kang MENG Hui SHEN Tao ZHANG Hua 

机构地区：[1]School of Biological Science and Technology,University of Jinan,Jinan 250022,China [2]Key Laboratory of Chemical Biology(MOE),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China

出　　处：《Chinese Journal of Natural Medicines》2022年第4期301-308,共8页中国天然药物（英文版）

基　　金：This work was supported by the Natural Science Foundation of Shandong Province(No.JQ201721);the Young Taishan Scholars Program(No.tsqn20161037);Innovation Team Project of Jinan Science&Technology Bureau(No.2018GXRC003).

摘　　要：Chemical fractionation of the n-BuOH partition,which was generated from the EtOH extract of the flower buds of Tussilago farfara,afforded a series of polar constituents including four new sesquiterpenoids(1-4),one new sesquiterpenoid glucoside(5)and one known analogue(6)of the eudesmane type,as well as five known quinic acid derivatives(7-11).Structures of the new compounds were unambiguously characterized by detailed spectroscopic analyses,with their absolute configurations being established by A-ray crystallography,electronic circular dichroism(ECD)calculation and induced ECD experiments.The inhibitory effect of all the isolates against LPS-induced NO production in murine RAW264.7 macrophages was evaluated,with isochlorogenic acid A(7)showing significant inhibitory activity.

关 键 词：Tussilago farfara Eudesmane sesquiterpenoid ANTI-INFLAMMATION NO production inhibition Quinic acid derivative 

分 类 号：R284[医药卫生—中药学]