血清铁蛋白、癌胚抗原、糖类抗原15-3联合检测在乳腺癌诊断、复发转移预测中的价值分析  

Value of serum ferritin,carcinoembryonic antigen and carbohydrate antigen 15-3 combined detection in diagnosis of breast cancer and prediction of recurrence and metastasis

作　　者：赵媛媛[1] 王帅力[1] 高晓莉[1] ZHAO Yuanyuan;WANG Shuaili;GAO Xiaoli(Department of Laboratory Medicine,Baoji Maternal and Child Health Hospital,Baoji 721000,Shaanxi,China)

机构地区：[1]宝鸡市妇幼保健院检验科,陕西宝鸡7210000

出　　处：《癌症进展》2022年第9期956-958,共3页Oncology Progress

摘　　要：目的分析血清铁蛋白(SF)、癌胚抗原(CEA)、糖类抗原15-3(CA15-3)联合检测在乳腺癌诊断、复发转移预测中的价值。方法选取278例乳腺疾病患者,病理检查结果显示,其中142例为乳腺癌患者(观察组),136例为良性乳腺疾病患者(对照组)。对比观察组与对照组患者血清SF、CEA、CA15-3水平,对患者进行为期1年的随访,了解乳腺癌患者复发转移情况,对比复发转移与未复发转移患者血清SF、CEA、CA15-3水平,分析SF、CEA、CA15-3联合检测对乳腺癌复发转移的预测价值。结果观察组患者血清SF、CEA、CA15-3水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。复发转移组患者血清SF、CEA、CA15-3水平均明显高于未复发转移组,差异均有统计学意义(P﹤0.01)。SF、CEA、CA15-3联合检测预测乳腺癌复发转移的灵敏度和特异度分别为88.0%、76.0%,曲线下面积(AUC)为0.752(95%CI:0.653~0.850),分别高于SF、CEA、CA15-3三者单独检测。结论SF、CEA、CA15-3在乳腺癌中均为高水平,三者联合检测可为乳腺癌患者复发转移评估提供参考依据,治疗后SF、CEA、CA15-3仍为高水平需要高度怀疑肿瘤出现复发转移。Objective To analyze the value of serum ferritin(SF),carcinoembryonic antigen(CEA)and carbohydrate antigen 15-3(CA15-3)combined detection in diagnosis of breast cancer and prediction of recurrence and metastasis.Method A total of 278 patients with breast diseases were selected,of which 142 were breast cancer patients(observation group)and 136 were benign breast diseases patients(control group).The expression of SF,CEA,and CA15-3 between the two groups were compared.All patients were followed up for 1 year to assess the recurrence and metastasis of breast cancer patients.The expression of SF,CEA,and CA15-3 in recurrence and metastasis versus non-recurrence and metasta-sis were compared to analyze the predictive value of combined detection of SF,CEA,and CA15-3 for breast cancer recur-rence and metastasis.Result The expressions of SF,CEA and CA15-3 in the observation group were significantly high-er than those in the control group(P<0.01);expressions of SF,CEA and CA15-3 in patients with recurrence and metasta-sis were higher than those in patients without recurrence and metastasis(P<0.01).The sensitivity and specificity of the combined detection of SF,CEA,and CA15-3 for breast cancer recurrence and metastasis were 88.0%and 76.0%,respec-tively,and the area under the curve(AUC)was 0.752(95%CI:0.653-0.850),which was higher than SF,CEA,and CA15-3 single detection.Conclusion SF,CEA,and CA15-3 are all highly expressed in breast cancer,the combined diagnosis can provide a reference basis for the evaluation of recurrence and metastasis of patients.Recurrence and metastasis are highly suspected if SF,CEA,and CA15-3 are still highly expressed after treatment.

关 键 词：血清铁蛋白 癌胚抗原 糖类抗原15-3 乳腺癌 诊断 复发转移 

分 类 号：R737.9[医药卫生—肿瘤]