经后腹腔入路腹腔镜肾部分切除术治疗早期肾癌的临床疗效及对免疫功能和生活质量的影响  

Clinical efficacy of laparoscopic partial nephrectomy via retroperitoneal approach in the treatment of early renal cancer and its influence on immune function and quality of life

作　　者：赵学军 张二峰 李国栋 ZHAO Xuejun;ZHANG Erfeng;LI Guodong(Department of Urology Surgery,Pingdingshan the Second People’s Hospital,Pingdingshan 467000,He’nan,China)

机构地区：[1]平顶山市第二人民医院泌尿外科,河南平顶山4670000

出　　处：《癌症进展》2022年第9期962-965,共4页Oncology Progress

摘　　要：目的探讨经后腹腔入路腹腔镜肾部分切除术治疗早期肾癌的临床疗效及对免疫功能和生活质量的影响。方法根据手术治疗方法的不同将80例早期肾癌患者分为观察组和对照组,每组40例,观察组患者采用经后腹腔入路腹腔镜肾部分切除术,对照组患者采用经腹入路腹腔镜肾部分切除术。比较两组患者的临床疗效、手术相关指标、免疫功能指标及生活质量。结果两组患者的总有效率比较,差异无统计学意义(P﹥0.05)。观察组患者的手术通道建立时间、手术时间均明显短于对照组,术中和术后出血量均明显少于对照组,差异均有统计学意义(P﹤0.01)。术后,两组患者的CD3+、CD4+水平及CD4+/CD8+均低于本组术前,观察组患者的CD8+水平高于本组术前,观察组患者的CD3+、CD4+、CD8+水平及CD4+/CD8+均高于对照组,差异均有统计学意义(P﹤0.05)。术后,两组患者的躯体功能、角色功能、情绪功能、认知功能及社会功能评分均高于本组术前,且观察组患者的上述评分均高于对照组,差异均有统计学意义(P﹤0.05)。结论与经腹入路腹腔镜肾部分切除术相比,经后腹腔入路腹腔镜肾部分切除术治疗早期肾癌的临床疗效较好,患者出血量较少,有利于加快患者免疫功能恢复,提高患者生活质量。Objective To investigate the clinical efficacy of laparoscopic partial nephrectomy via retroperitoneal ap-proach in the treatment of early renal cancer and its influence on immune function and quality of life.Method A total of 80 patients with early renal cancer were divided into observation group and control group according to different surgical treatment methods with 40 cases in either group.The patients in the observation group were treated with laparoscopic par-tial nephrectomy via retroperitoneal approach,and the patients in the control group were treated with laparoscopic partial nephrectomy via abdominal approach.The clinical efficacy,surgery-related indicators,immune function indicators,and quality of life were compared between the two groups.Result There was no significant difference in the total response rate between the two groups(P>0.05).The surgical channel establishment time and the operation time of the observation group were significantly shorter than those of the control group,and the intraoperative and postoperative blood loss were significantly less than those of the control group,and the differences were statistically significant(P<0.01).After the oper-ation,the levels of CD3+,CD4+,and CD4+/CD8+in the two groups were lower than those before the operation,and the lev-el of CD8+in the observation group was higher than that before the operation,the levels of CD3+,CD4+,CD8+,and CD4+/CD8+in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After the operation,the physical function,role function,emotional function,cognitive function,and social func-tion scores of the two groups were higher than those before the operation,and the foregoing scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Laparoscopic partial nephrectomy via retroperitoneal approach has better clinical efficacy with less blood loss compared with laparoscopic partial nep

关 键 词：经后腹腔入路 肾部分切除术 早期肾癌 临床疗效 免疫功能 生活质量 

分 类 号：R737.11[医药卫生—肿瘤]